BAIT
RNF11
SID1669, CGI-123
ring finger protein 11
GO Process (2)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
USP14
TGT
ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
GO Process (6)
GO Function (7)
GO Component (5)
Gene Ontology Biological Process
- negative regulation of ER-associated ubiquitin-dependent protein catabolic process [IMP]
- negative regulation of endopeptidase activity [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein deubiquitination [IDA]
- regulation of chemotaxis [IMP]
- regulation of proteasomal protein catabolic process [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response.
Protein modifications by ubiquitin and small ubiquitin-like modifier (SUMO) play key roles in cellular signaling pathways. SUMO-targeted ubiquitin ligases (STUbLs) directly couple these modifications by selectively recognizing SUMOylated target proteins through SUMO-interacting motifs (SIMs), promoting their K48-linked ubiquitylation and degradation. Only a single mammalian STUbL, RNF4, has been identified. We show that human RNF111/Arkadia is a new STUbL, which used ... [more]
J. Cell Biol. Jun. 10, 2013; 201(6);797-807 [Pubmed: 23751493]
Throughput
- Low Throughput
Curated By
- BioGRID