BAIT
PGRP-LE
CG8995, Dmel\CG8995, PGRP, anon-WO0153538.66, Dmel_CG8995
Peptidoglycan recognition protein LE
GO Process (11)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- defense response [NAS]
- defense response to Gram-negative bacterium [IGI, IMP]
- defense response to Gram-positive bacterium [IDA]
- defense response to bacterium [IMP]
- determination of adult lifespan [IMP]
- immune response [IMP, ISS, TAS]
- peptidoglycan catabolic process [IKR]
- peptidoglycan recognition protein signaling pathway [IDA]
- positive regulation of innate immune response [IMP]
- response to bacterium [IMP]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
PREY
CG1943
Dmel\CG1943, Dmel_CG1943
CG1943 gene product from transcript CG1943-RD
GO Process (1)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Drosophila melanogaster
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge.
The Drosophila defense against pathogens largely relies on the activation of two signaling pathways: immune deficiency (IMD) and Toll. The IMD pathway is triggered mainly by Gram-negative bacteria, whereas the Toll pathway responds predominantly to Gram-positive bacteria and fungi. The activation of these pathways leads to the rapid induction of numerous NF-κB-induced immune response genes, including antimicrobial peptide genes. The ... [more]
Proc. Natl. Acad. Sci. U.S.A. Jun. 07, 2013; 0(0); [Pubmed: 23749869]
Throughput
- High Throughput
Curated By
- BioGRID