BAIT
KEY
CG16910, DmIKK-gamma, DmIKKgamma, Dmel\CG16910, IKK, IKK-gamma, IKKG, IKK[[gamma]], IKKgamma, Kenny, dIKK, dIKK-gamma, Dmel_CG16910
kenny
GO Process (11)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- Toll signaling pathway [TAS]
- antimicrobial humoral response [NAS]
- defense response to Gram-negative bacterium [IMP]
- defense response to virus [IMP]
- immune response [IMP]
- negative regulation of stem cell proliferation [IMP]
- positive regulation of antibacterial peptide biosynthetic process [IMP, NAS]
- positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria [IMP]
- positive regulation of defense response to virus by host [IMP]
- positive regulation of innate immune response [IMP]
- protein catabolic process [IDA]
Gene Ontology Molecular Function
Drosophila melanogaster
PREY
SMT3
CG4494, Dm0342, DmSUMO-1, DmSmt3, Dmel\CG4494, SUMO, anon-EST:Posey240, dSmt3, l(2)04493, l(2)SH0182, l(2)SH2 0182, Dmel_CG4494
CG4494 gene product from transcript CG4494-RA
GO Process (17)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- anterior/posterior pattern specification [IMP]
- cellular protein modification process [IGI, IPI]
- cellular response to transforming growth factor beta stimulus [IGI]
- central nervous system projection neuron axonogenesis [IMP]
- dendritic spine morphogenesis [IMP]
- dorsal appendage formation [IMP]
- lipid homeostasis [IMP]
- mitotic spindle organization [IMP]
- phagocytosis [IMP]
- positive regulation of MAP kinase activity [IMP]
- positive regulation of Ras protein signal transduction [IMP]
- protein desumoylation [IGI]
- protein import into nucleus [IGI, IPI]
- protein sumoylation [IDA]
- pupariation [IMP]
- syncytial blastoderm mitotic cell cycle [IMP]
- tricarboxylic acid cycle [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Drosophila melanogaster
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Landscape of protein-protein interactions in Drosophila immune deficiency signaling during bacterial challenge.
The Drosophila defense against pathogens largely relies on the activation of two signaling pathways: immune deficiency (IMD) and Toll. The IMD pathway is triggered mainly by Gram-negative bacteria, whereas the Toll pathway responds predominantly to Gram-positive bacteria and fungi. The activation of these pathways leads to the rapid induction of numerous NF-κB-induced immune response genes, including antimicrobial peptide genes. The ... [more]
Proc. Natl. Acad. Sci. U.S.A. Jun. 07, 2013; 0(0); [Pubmed: 23749869]
Throughput
- High Throughput
Curated By
- BioGRID