BAIT
ADRB2
ADRB2R, ADRBR, B2AR, BAR, BETA2AR
adrenoceptor beta 2, surface
GO Process (10)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- activation of adenylate cyclase activity [IDA]
- activation of transmembrane receptor protein tyrosine kinase activity [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- adrenergic receptor signaling pathway [IDA]
- cell surface receptor signaling pathway [TAS]
- desensitization of G-protein coupled receptor protein signaling pathway by arrestin [IDA]
- endosome to lysosome transport [TAS]
- positive regulation of MAPK cascade [IDA]
- positive regulation of protein ubiquitination [IMP]
- receptor-mediated endocytosis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
LONP1
LON, LONP, LonHS, PIM1, PRSS15, hLON
lon peptidase 1, mitochondrial
GO Process (8)
GO Function (12)
GO Component (5)
Gene Ontology Biological Process
- cellular response to oxidative stress [IC, IDA]
- mitochondrial DNA metabolic process [NAS]
- mitochondrial genome maintenance [NAS]
- mitochondrion organization [IMP]
- oxidation-dependent protein catabolic process [IMP]
- protein homooligomerization [IDA]
- proteolysis involved in cellular protein catabolic process [IDA]
- response to hypoxia [IEP]
Gene Ontology Molecular Function- ADP binding [IDA]
- ATP binding [IDA]
- ATP-dependent peptidase activity [IDA]
- DNA polymerase binding [IPI]
- G-quadruplex DNA binding [IDA]
- mitochondrial heavy strand promoter anti-sense binding [IDA]
- mitochondrial heavy strand promoter sense binding [IDA]
- mitochondrial light strand promoter anti-sense binding [IDA]
- mitochondrial light strand promoter sense binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- single-stranded RNA binding [IDA]
- ADP binding [IDA]
- ATP binding [IDA]
- ATP-dependent peptidase activity [IDA]
- DNA polymerase binding [IPI]
- G-quadruplex DNA binding [IDA]
- mitochondrial heavy strand promoter anti-sense binding [IDA]
- mitochondrial heavy strand promoter sense binding [IDA]
- mitochondrial light strand promoter anti-sense binding [IDA]
- mitochondrial light strand promoter sense binding [IDA]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- single-stranded RNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Novel, gel-free proteomics approach identifies RNF5 and JAMP as modulators of GPCR stability.
The maturation and folding of G protein-coupled receptors (GPCRs) are governed by mechanisms that remain poorly understood. In an effort to characterize these biological events, we optimized a novel, gel-free proteomic approach to identify partners of the β2-adrenergic receptor (β2AR). In addition to a number of known interacting proteins such as heterotrimeric G protein subunits, this allowed us to identify ... [more]
Mol. Endocrinol. Jun. 24, 2013; 0(0); [Pubmed: 23798571]
Throughput
- High Throughput
Ontology Terms
- hek-293 cell (BTO:0000007)
Additional Notes
- exogenous expression of bait
Curated By
- BioGRID