BAIT

SUMO3

2810014B19Rik, D10Ertd345e, SMT3A, SUMO-3, Smt3h1
SMT3 suppressor of mif two 3 homolog 3 (yeast)
Mus musculus
PREY

SENP6

2810017C20Rik, E130319N12Rik, Susp1, mKIAA0797
SUMO/sentrin specific peptidase 6
GO Process (5)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus

Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.

Publication

Negative Regulation of TLR Inflammatory Signaling by the SUMO-deconjugating Enzyme SENP6.

Liu X, Chen W, Wang Q, Li L, Wang C

The signaling of Toll-like receptors (TLRs) induces host defense against microbial invasion. Protein posttranslational modifications dynamically shape the strength and duration of the signaling pathways. It is intriguing to explore whether de-SUMOylation could modulate the TLR signaling. Here we identified SUMO-specific protease 6 (SENP6) as an intrinsic attenuator of the TLR-triggered inflammation. Depletion of SENP6 significantly potentiated the NF-κB-mediated induction ... [more]

PLoS Pathog. Jun. 01, 2013; 9(6);e1003480 [Pubmed: 23825957]

Throughput

  • Low Throughput

Additional Notes

  • #LPPI
  • Likely protein-protein interaction

Curated By

  • BioGRID