BAIT

BAG3

BAG-3, BIS, CAIR-1, MFM6

BCL2-associated athanogene 3

Alzheimer's Disease Project

GO Process (3)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

extrinsic apoptotic signaling pathway via death domain receptors [IDA]

negative regulation of apoptotic process [NAS]

protein folding [NAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

plasma membrane [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

PDCD6IP

AIP1, ALIX, DRIP4, HP95

programmed cell death 6 interacting protein

GO Process (7)

GO Function (4)

GO Component (8)

Gene Ontology Biological Process

positive regulation of exosomal secretion [IMP]

positive regulation of extracellular vesicular exosome assembly [IMP]

regulation of extracellular vesicular exosome assembly [IMP]

ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway [IMP]

viral budding via host ESCRT complex [IGI]

viral life cycle [TAS]

viral process [TAS]

Gene Ontology Molecular Function

calcium-dependent protein binding [IPI]
protein binding [IPI]
protein homodimerization activity [IPI]
proteinase activated receptor binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

endoplasmic reticulum exit site [IMP]

extracellular vesicular exosome [IDA]

focal adhesion [IDA]

immunological synapse [IDA]

CRISPR Database VEGA OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

BAG3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity.

Chen Y, Yang LN, Cheng L, Tu S, Guo SJ, Le HY, Xiong Q, Mo R, Li CY, Jeong JS, Jiang L, Blackshaw S, Bi LJ, Zhu H, Tao SC, Ge F

Bcl2-associated athanogene 3 (BAG3), a member of the BAG family of co-chaperones, plays a critical role in regulating apoptosis, development, cell motility, autophagy, and tumor metastasis, and in mediating cell adaptive responses to stressful stimuli. BAG3 carries a BAG domain, a WW domain and a proline-rich (PXXP) repeat, all of which mediate binding to different partners. To elucidate BAG3 interaction ... [more]

Mol. Cell Proteomics Jul. 03, 2013; 0(0); [Pubmed: 23824909]

Throughput

High Throughput

Curated By

BioGRID