BAIT

BAG3

BAG-3, BIS, CAIR-1, MFM6

BCL2-associated athanogene 3

Alzheimer's Disease Project

Parkinson's Disease Project

GO Process (3)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

extrinsic apoptotic signaling pathway via death domain receptors [IDA]

negative regulation of apoptotic process [NAS]

protein folding [NAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

plasma membrane [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

UBE2C

UBCH10, dJ447F3.2, RP3-447F3.1

ubiquitin-conjugating enzyme E2C

Cell Cycle - Senescence Project

GO Process (16)

GO Function (6)

GO Component (4)

Gene Ontology Biological Process

activation of anaphase-promoting complex activity [TAS]

anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process [IDA, TAS]

exit from mitosis [IMP]

free ubiquitin chain polymerization [IDA]

mitotic cell cycle [TAS]

mitotic spindle assembly checkpoint [TAS]

negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation [IDA]

negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]

positive regulation of exit from mitosis [IMP]

positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]

protein K11-linked ubiquitination [IDA]

protein K48-linked ubiquitination [IDA]

protein ubiquitination [IDA]

regulation of mitotic metaphase/anaphase transition [IBA]

regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [TAS]

ubiquitin-dependent protein catabolic process [IDA]

Gene Ontology Molecular Function

protein binding [IPI]
small conjugating protein transferase activity [IBA]
ubiquitin conjugating enzyme activity [IDA]
ubiquitin protein ligase activity [IBA]
ubiquitin protein ligase binding [IBA]
ubiquitin-protein transferase activity [IDA]

Gene Ontology Cellular Component

anaphase-promoting complex [IDA]

cytoplasm [IBA]

nucleoplasm [TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

BAG3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity.

Chen Y, Yang LN, Cheng L, Tu S, Guo SJ, Le HY, Xiong Q, Mo R, Li CY, Jeong JS, Jiang L, Blackshaw S, Bi LJ, Zhu H, Tao SC, Ge F

Bcl2-associated athanogene 3 (BAG3), a member of the BAG family of co-chaperones, plays a critical role in regulating apoptosis, development, cell motility, autophagy, and tumor metastasis, and in mediating cell adaptive responses to stressful stimuli. BAG3 carries a BAG domain, a WW domain and a proline-rich (PXXP) repeat, all of which mediate binding to different partners. To elucidate BAG3 interaction ... [more]

Mol. Cell Proteomics Jul. 03, 2013; 0(0); [Pubmed: 23824909]

Throughput

High Throughput

Curated By

BioGRID