BAIT

BAG3

BAG-3, BIS, CAIR-1, MFM6

BCL2-associated athanogene 3

Alzheimer's Disease Project

Parkinson's Disease Project

GO Process (3)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

extrinsic apoptotic signaling pathway via death domain receptors [IDA]

negative regulation of apoptotic process [NAS]

protein folding [NAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

plasma membrane [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

GH1

GH, GH-N, GHN, IGHD1B, hGH-N

growth hormone 1

GO Process (16)

GO Function (4)

GO Component (2)

Gene Ontology Biological Process

JAK-STAT cascade [IDA]

JAK-STAT cascade involved in growth hormone signaling pathway [TAS]

bone maturation [IDA]

glucose transport [IDA]

growth hormone receptor signaling pathway [IDA]

positive regulation of JAK-STAT cascade [IDA]

positive regulation of MAP kinase activity [TAS]

positive regulation of activation of JAK2 kinase activity [IDA]

positive regulation of insulin-like growth factor receptor signaling pathway [IDA]

positive regulation of multicellular organism growth [IDA, IMP]

positive regulation of peptidyl-tyrosine phosphorylation [IDA]

positive regulation of phosphatidylinositol 3-kinase signaling [IDA]

positive regulation of receptor internalization [IDA]

positive regulation of tyrosine phosphorylation of Stat3 protein [IDA]

positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]

response to estradiol [IDA]

Gene Ontology Molecular Function

growth factor activity [IPI]
growth hormone receptor binding [IDA, IPI]
prolactin receptor binding [IPI]
protein binding [IPI]

Gene Ontology Cellular Component

extracellular region [TAS]

extracellular space [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Affinity Capture-Luminescence

An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag.

Publication

BAG3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity.

Chen Y, Yang LN, Cheng L, Tu S, Guo SJ, Le HY, Xiong Q, Mo R, Li CY, Jeong JS, Jiang L, Blackshaw S, Bi LJ, Zhu H, Tao SC, Ge F

Bcl2-associated athanogene 3 (BAG3), a member of the BAG family of co-chaperones, plays a critical role in regulating apoptosis, development, cell motility, autophagy, and tumor metastasis, and in mediating cell adaptive responses to stressful stimuli. BAG3 carries a BAG domain, a WW domain and a proline-rich (PXXP) repeat, all of which mediate binding to different partners. To elucidate BAG3 interaction ... [more]

Mol. Cell Proteomics Jul. 03, 2013; 0(0); [Pubmed: 23824909]

Throughput

High Throughput

Curated By

BioGRID