BAIT

BAG3

BAG-3, BIS, CAIR-1, MFM6

BCL2-associated athanogene 3

Alzheimer's Disease Project

GO Process (3)

GO Function (1)

GO Component (3)

Gene Ontology Biological Process

extrinsic apoptotic signaling pathway via death domain receptors [IDA]

negative regulation of apoptotic process [NAS]

protein folding [NAS]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

plasma membrane [IDA]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

POLR2H

RPABC3, RPB17, RPB8

polymerase (RNA) II (DNA directed) polypeptide H

GO Process (21)

GO Function (3)

GO Component (6)

Gene Ontology Biological Process

7-methylguanosine mRNA capping [TAS]

DNA repair [TAS]

RNA splicing [TAS]

gene expression [TAS]

innate immune response [TAS]

mRNA splicing, via spliceosome [TAS]

nucleotide-excision repair [TAS]

positive regulation of type I interferon production [TAS]

positive regulation of viral transcription [TAS]

termination of RNA polymerase I transcription [TAS]

termination of RNA polymerase III transcription [TAS]

transcription elongation from RNA polymerase I promoter [TAS]

transcription elongation from RNA polymerase II promoter [TAS]

transcription elongation from RNA polymerase III promoter [TAS]

transcription from RNA polymerase I promoter [TAS]

transcription from RNA polymerase II promoter [IDA, TAS]

transcription from RNA polymerase III promoter [TAS]

transcription initiation from RNA polymerase I promoter [TAS]

transcription initiation from RNA polymerase II promoter [TAS]

transcription-coupled nucleotide-excision repair [TAS]

viral process [TAS]

Gene Ontology Molecular Function

RNA polymerase I activity [IBA]
RNA polymerase II activity [IBA]
RNA polymerase III activity [IBA]

Gene Ontology Cellular Component

DNA-directed RNA polymerase I complex [IBA]

DNA-directed RNA polymerase II, core complex [IDA]

DNA-directed RNA polymerase III complex [IBA]

nucleoplasm [IDA, TAS]

CRISPR Database VEGA HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-Luminescence

An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag.

Publication

BAG3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity.

Chen Y, Yang LN, Cheng L, Tu S, Guo SJ, Le HY, Xiong Q, Mo R, Li CY, Jeong JS, Jiang L, Blackshaw S, Bi LJ, Zhu H, Tao SC, Ge F

Bcl2-associated athanogene 3 (BAG3), a member of the BAG family of co-chaperones, plays a critical role in regulating apoptosis, development, cell motility, autophagy, and tumor metastasis, and in mediating cell adaptive responses to stressful stimuli. BAG3 carries a BAG domain, a WW domain and a proline-rich (PXXP) repeat, all of which mediate binding to different partners. To elucidate BAG3 interaction ... [more]

Mol. Cell Proteomics Jul. 03, 2013; 0(0); [Pubmed: 23824909]

Throughput

High Throughput

Curated By

BioGRID