BAIT
BAG3
BAG-3, BIS, CAIR-1, MFM6
BCL2-associated athanogene 3
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
TFAP2A
AP-2, AP-2alpha, AP2TF, BOFS, TFAP2, RP1-290I10.1
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
GO Process (28)
GO Function (15)
GO Component (6)
Gene Ontology Biological Process
- bone morphogenesis [ISS]
- cellular response to iron ion [IDA]
- embryonic cranial skeleton morphogenesis [ISS]
- embryonic forelimb morphogenesis [ISS]
- eyelid development in camera-type eye [ISS]
- inner ear morphogenesis [IMP]
- kidney development [IMP]
- negative regulation of apoptotic process [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of reactive oxygen species metabolic process [IDA]
- negative regulation of transcription by competitive promoter binding [IDA, IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- oculomotor nerve formation [ISS]
- optic cup structural organization [ISS]
- optic vesicle morphogenesis [ISS]
- palate development [IMP]
- positive regulation of bone mineralization [IDA]
- positive regulation of gene expression [ISS]
- positive regulation of neuron apoptotic process [IDA]
- positive regulation of tooth mineralization [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IDA, ISS]
- regulation of cell differentiation [IDA]
- retina layer formation [IEP]
- sensory perception of sound [IMP]
- transcription from RNA polymerase II promoter [IDA]
- trigeminal nerve development [ISS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- chromatin binding [ISS]
- core promoter proximal region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein homodimerization activity [TAS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- chromatin binding [ISS]
- core promoter proximal region sequence-specific DNA binding [IDA]
- protein binding [IPI]
- protein dimerization activity [IDA]
- protein homodimerization activity [TAS]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription coactivator activity [IDA]
- transcription regulatory region DNA binding [IDA]
- transcription regulatory region sequence-specific DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-Luminescence
An interaction is inferred when a bait protein, tagged with luciferase, is enzymatically detected in immunoprecipitates of the prey protein as light emission. The prey protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag.
Publication
BAG3 Interactome Analysis Reveals a New Role in Modulating Proteasome Activity.
Bcl2-associated athanogene 3 (BAG3), a member of the BAG family of co-chaperones, plays a critical role in regulating apoptosis, development, cell motility, autophagy, and tumor metastasis, and in mediating cell adaptive responses to stressful stimuli. BAG3 carries a BAG domain, a WW domain and a proline-rich (PXXP) repeat, all of which mediate binding to different partners. To elucidate BAG3 interaction ... [more]
Mol. Cell Proteomics Jul. 03, 2013; 0(0); [Pubmed: 23824909]
Throughput
- High Throughput
Curated By
- BioGRID