BAIT
PIK3C3
VPS34, hVps34
phosphatidylinositol 3-kinase, catalytic subunit type 3
GO Process (10)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
- cytokinesis [IMP]
- early endosome to late endosome transport [IMP]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol-3-phosphate biosynthetic process [IMP, TAS]
- phospholipid metabolic process [TAS]
- small molecule metabolic process [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
KIF1B
CMT2, CMT2A, CMT2A1, HMSNII, KLP, NBLST1, RP4-736L20.1
kinesin family member 1B
GO Process (6)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy.
Autophagy is a stress-induced catabolic process in which cytoplasmic components, sequestered in double-membrane autophagic vesicles (AVs) or autophagosomes, are delivered to lysosomes for degradation and recycling [Kroemer G, Marino G, Levine B (2010) Mol Cell 40(2):280-293]. Activity of the class III phosphatidylinositol-3-OH-kinase (PI3K) vacuolar protein-sorting (Vps) 34, bound to coiled-coil moesin-like B-cell lymphoma 2 (Bcl-2)-interacting protein Beclin-1, is required for ... [more]
Proc. Natl. Acad. Sci. U.S.A. Apr. 23, 2013; 110(17);6841-6 [Pubmed: 23569248]
Throughput
- Low Throughput
Curated By
- BioGRID