PIK3C3
Gene Ontology Biological Process
- autophagic vacuole assembly [ISO]
- cytokinesis [ISO]
- early endosome to late endosome transport [ISO]
- endosome organization [ISO]
- phosphatidylinositol phosphorylation [IBA]
- phosphatidylinositol-3-phosphate biosynthetic process [IBA, ISO]
- phosphatidylinositol-mediated signaling [ISO]
- protein phosphorylation [IMP]
- protein processing [ISO]
- regulation of protein secretion [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BECN1
Gene Ontology Biological Process
- CVT pathway [IBA]
- autophagic vacuole assembly [IBA, ISO]
- autophagy [IDA, IMP, ISO]
- beta-amyloid metabolic process [IMP]
- cellular response to nitrogen starvation [IBA]
- cytokinesis [ISO]
- late endosome to vacuole transport [IBA]
- lysosome organization [IMP]
- negative regulation of cell death [ISO]
- negative regulation of cell proliferation [IDA]
- neuron development [IMP]
- nucleophagy [IBA]
- positive regulation of autophagy [ISO]
- positive regulation of macroautophagy [IGI]
- positive regulation of mitochondrion degradation [ISO]
- regulation of catalytic activity [IMP]
- response to other organism [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoskeleton [ISS]
- dendrite [ISO]
- extrinsic component of membrane [IBA]
- membrane [ISS]
- nucleus [ISO]
- phagocytic vesicle [IDA]
- phosphatidylinositol 3-kinase complex, class III, type I [IBA]
- phosphatidylinositol 3-kinase complex, class III, type II [IBA]
- pre-autophagosomal structure [IBA]
- protein complex [IDA]
- trans-Golgi network [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy.
Autophagy is a stress-induced catabolic process in which cytoplasmic components, sequestered in double-membrane autophagic vesicles (AVs) or autophagosomes, are delivered to lysosomes for degradation and recycling [Kroemer G, Marino G, Levine B (2010) Mol Cell 40(2):280-293]. Activity of the class III phosphatidylinositol-3-OH-kinase (PI3K) vacuolar protein-sorting (Vps) 34, bound to coiled-coil moesin-like B-cell lymphoma 2 (Bcl-2)-interacting protein Beclin-1, is required for ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID