BAIT
CSF2
GMCSF
colony stimulating factor 2 (granulocyte-macrophage)
GO Process (9)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- dendritic cell differentiation [IDA]
- negative regulation of cytolysis [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- positive regulation of DNA replication [IDA]
- positive regulation of gene expression [IDA]
- positive regulation of interleukin-23 production [IDA]
- positive regulation of macrophage derived foam cell differentiation [IDA]
- positive regulation of podosome assembly [IDA]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PABPC1
PAB1, PABP, PABP1, PABPC2, PABPL1
poly(A) binding protein, cytoplasmic 1
GO Process (17)
GO Function (6)
GO Component (10)
Gene Ontology Biological Process
- RNA metabolic process [TAS]
- cellular protein metabolic process [TAS]
- gene expression [TAS]
- gene silencing by RNA [ISS]
- mRNA metabolic process [TAS]
- mRNA polyadenylation [TAS]
- mRNA splicing, via spliceosome [IC]
- mRNA stabilization [TAS]
- negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IDA]
- nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [TAS]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [TAS]
- nuclear-transcribed mRNA poly(A) tail shortening [TAS]
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [ISS]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [ISS]
- positive regulation of translation [TAS]
- translation [TAS]
- translational initiation [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Affinity purification of ARE-binding proteins identifies polyA-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization.
An important determinant for the expression level of cytokines and proto-oncogenes is the rate of degradation of their mRNAs. AU-rich sequence elements (AREs) in the 3(') untranslated regions have been found to impose rapid decay of these mRNAs. ARE-containing mRNAs can be stabilized in response to external signals which activate the p38 MAP kinase cascade including the p38 MAP kinase ... [more]
Biochem. Biophys. Res. Commun. Feb. 14, 2003; 301(3);665-70 [Pubmed: 12565831]
Throughput
- Low Throughput
Ontology Terms
- adenocarcinoma (DOID:299)
- hela cell (BTO:0000567)
Curated By
- BioGRID