BAIT

CSF2

GMCSF

colony stimulating factor 2 (granulocyte-macrophage)

GO Process (9)

GO Function (1)

GO Component (1)

Gene Ontology Biological Process

dendritic cell differentiation [IDA]

negative regulation of cytolysis [IDA]

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]

positive regulation of DNA replication [IDA]

positive regulation of gene expression [IDA]

positive regulation of interleukin-23 production [IDA]

positive regulation of macrophage derived foam cell differentiation [IDA]

positive regulation of podosome assembly [IDA]

positive regulation of tyrosine phosphorylation of Stat5 protein [IDA]

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

extracellular region [TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

SYNCRIP

GRY-RBP, GRYRBP, HNRNPQ, HNRPQ1, NSAP1, PP68, hnRNP-Q, RP1-3J17.2

synaptotagmin binding, cytoplasmic RNA interacting protein

Autism spectrum disorder (ASD) Project

GO Process (7)

GO Function (3)

GO Component (7)

Gene Ontology Biological Process

CRD-mediated mRNA stabilization [IMP]

RNA processing [TAS]

RNA splicing [TAS]

cellular response to interferon-gamma [IDA]

mRNA splicing, via spliceosome [IC]

negative regulation of translation [IDA, IMP]

osteoblast differentiation [IDA]

Gene Ontology Molecular Function

RNA binding [TAS]
poly(A) RNA binding [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

CRD-mediated mRNA stability complex [IDA]

GAIT complex [IDA]

catalytic step 2 spliceosome [IDA]

histone pre-mRNA 3'end processing complex [ISS]

ribonucleoprotein complex [IDA]

CRISPR Database HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Affinity Capture-RNA

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.

Publication

Affinity purification of ARE-binding proteins identifies polyA-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization.

Bollig F, Winzen R, Gaestel M, Kostka S, Resch K, Holtmann H

An important determinant for the expression level of cytokines and proto-oncogenes is the rate of degradation of their mRNAs. AU-rich sequence elements (AREs) in the 3(') untranslated regions have been found to impose rapid decay of these mRNAs. ARE-containing mRNAs can be stabilized in response to external signals which activate the p38 MAP kinase cascade including the p38 MAP kinase ... [more]

Biochem. Biophys. Res. Commun. Feb. 14, 2003; 301(3);665-70 [Pubmed: 12565831]

Throughput

Low Throughput

Ontology Terms

cell line: hela cell (BTO:0000567)
disease: adenocarcinoma (DOID:299)

Curated By

BioGRID