An interaction is inferred when close proximity of interaction partners is detected by fluorescence resonance energy transfer between pairs of fluorophore-labeled molecules, such as occurs between CFP (donor) and YFP (acceptor) fusion proteins.

Publication

Networks of bZIP protein-protein interactions diversified over a billion years of evolution.

Reinke AW, Baek J, Ashenberg O, Keating AE

Differences in biomolecular sequence and function underlie dramatic ranges of appearance and behavior among species. We studied the basic region-leucine zipper (bZIP) transcription factors and quantified bZIP dimerization networks for five metazoan and two single-cell species, measuring interactions in vitro for 2891 protein pairs. Metazoans have a higher proportion of heteromeric bZIP interactions and more network complexity than the single-cell ... [more]

Science May. 10, 2013; 340(6133);730-4 [Pubmed: 23661758]

Throughput

High Throughput

Curated By

BioGRID

Interaction Summary

CEBPA

Gene Ontology Biological Process

Gene Ontology Molecular Function

DNA binding [TAS]RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [NAS]protein binding [IPI]sequence-specific DNA binding transcription factor activity [IDA]transcription factor binding [IPI]transcription regulatory region DNA binding [IDA]

Gene Ontology Cellular Component

ATF5

Gene Ontology Biological Process

Gene Ontology Molecular Function

RNA polymerase II regulatory region sequence-specific DNA binding [IMP]RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]protein binding [IPI]transcription corepressor activity [TAS]

Gene Ontology Cellular Component

FRET

Publication

Networks of bZIP protein-protein interactions diversified over a billion years of evolution.

Throughput

Curated By

DNA binding [TAS]
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [NAS]
protein binding [IPI]
sequence-specific DNA binding transcription factor activity [IDA]
transcription factor binding [IPI]
transcription regulatory region DNA binding [IDA]

RNA polymerase II regulatory region sequence-specific DNA binding [IMP]
RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IC]
protein binding [IPI]
transcription corepressor activity [TAS]