PSD2
Gene Ontology Biological Process
Gene Ontology Molecular Function
MET30
Gene Ontology Biological Process
- DNA replication initiation [IMP]
- G1/S transition of mitotic cell cycle [IMP]
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IGI]
- protein polyubiquitination [IMP]
- protein ubiquitination [IGI, IPI]
- regulation of DNA-dependent DNA replication initiation [IMP]
- regulation of transcription involved in G1/S transition of mitotic cell cycle [IMP]
- response to arsenic-containing substance [IDA]
- response to cadmium ion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Growth Defect
A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell.
Publication
Phosphatidylserine transport to the mitochondria is regulated by ubiquitination.
Mitochondrial membrane biogenesis requires the interorganelle transport of phospholipids. Phosphatidylserine (PtdSer) synthesized in the endoplasmic reticulum and related membranes (mitochondria-associated membrane (MAM)) is transported to the mitochondria by unknown gene products and decarboxylated to form phosphatidylethanolamine at the inner membrane by PtdSer decarboxylase 1 (Psd1p). We have designed a screen for strains defective in PtdSer transport (pstA mutants) between the ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: small molecule transport (APO:0000130)
- phenotype: vegetative growth (APO:0000106)
- phenotype: temperature sensitive growth (APO:0000092)
Additional Notes
- ER-mitochondrial transport of phosphatidylserine and conversion to phosphatidylethanolamine was defective in double mutant
- psd2 mt30-6 double mutants did not grow at 36 degrees C
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MET30 PSD2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.264 | BioGRID | 388156 | |
| MET30 PSD2 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.2001 | BioGRID | 1989742 |
Curated By
- BioGRID