F2R
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISS]
- STAT protein import into nucleus [IDA]
- activation of MAPKK activity [ISS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- anatomical structure morphogenesis [TAS]
- blood coagulation [TAS]
- connective tissue replacement involved in inflammatory response wound healing [IDA]
- establishment of synaptic specificity at neuromuscular junction [ISS]
- homeostasis of number of cells within a tissue [ISS]
- inflammatory response [ISS]
- negative regulation of cell proliferation [IDA]
- negative regulation of glomerular filtration [ISS]
- negative regulation of neuron apoptotic process [ISS]
- negative regulation of renin secretion into blood stream [ISS]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- platelet activation [IDA, TAS]
- platelet dense granule organization [IC]
- positive regulation of ERK1 and ERK2 cascade [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IEP]
- positive regulation of JAK-STAT cascade [IDA]
- positive regulation of MAPK cascade [IDA]
- positive regulation of Rho protein signal transduction [ISS]
- positive regulation of blood coagulation [IDA]
- positive regulation of calcium ion transport [ISS]
- positive regulation of cell migration [IMP]
- positive regulation of cell proliferation [ISS]
- positive regulation of collagen biosynthetic process [IDA]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway [ISS]
- positive regulation of interleukin-6 secretion [IDA]
- positive regulation of interleukin-8 secretion [IDA]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [IDA]
- positive regulation of smooth muscle contraction [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vasoconstriction [ISS]
- protein kinase C-activating G-protein coupled receptor signaling pathway [ISS]
- regulation of blood coagulation [IDA]
- regulation of interleukin-1 beta production [ISS]
- regulation of sensory perception of pain [ISS]
- release of sequestered calcium ion into cytosol [ISS]
- response to lipopolysaccharide [ISS]
- response to wounding [IDA]
- tyrosine phosphorylation of STAT protein [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PROCR
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Factor X/Xa elicits protective signaling responses in endothelial cells directly via PAR-2 and indirectly via endothelial protein C receptor-dependent recruitment of PAR-1.
We recently demonstrated that the Gla domain-dependent interaction of protein C with endothelial protein C receptor (EPCR) leads to dissociation of the receptor from caveolin-1 and recruitment of PAR-1 to a protective signaling pathway. Thus, the activation of PAR-1 by either thrombin or PAR-1 agonist peptide elicited a barrier-protective response if endothelial cells were preincubated with protein C. In this ... [more]
Throughput
- Low Throughput
Ontology Terms
- cell line: eahy 926 cell (BTO:0000396)
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PROCR F2R | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | 879714 |
Curated By
- BioGRID