Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.


Biphasic incorporation of centromeric histone CENP-A in fission yeast.

Takayama Y, Sato H, Saitoh S, Ogiyama Y, Masuda F, Takahashi K

CENP-A is a centromere-specific histone H3 variant that is essential for kinetochore formation. Here, we report that the fission yeast Schizosaccharomyces pombe has at least two distinct CENP-A deposition phases across the cell cycle: S and G2. The S phase deposition requires Ams2 GATA factor, which promotes histone gene activation. In Delta ams2, CENP-A fails to retain during S, but ... [more]

Mol. Biol. Cell Feb. 01, 2008; 19(2);682-90 [Pubmed: 18077559]


  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Curated By