SHH
Gene Ontology Biological Process
- CD4-positive or CD8-positive, alpha-beta T cell lineage commitment [IDA]
- T cell differentiation in thymus [ISS]
- androgen metabolic process [ISS]
- apoptotic signaling pathway [ISS]
- axon guidance [ISS]
- branching involved in ureteric bud morphogenesis [ISS]
- branching morphogenesis of an epithelial tube [ISS]
- cell development [ISS]
- cell fate specification [ISS]
- cell-cell signaling [ISS]
- central nervous system development [ISS]
- cerebellar granule cell precursor proliferation [ISS]
- determination of left/right asymmetry in lateral mesoderm [ISS]
- dorsal/ventral pattern formation [ISS]
- embryo development [ISS]
- embryonic digit morphogenesis [ISS]
- embryonic limb morphogenesis [ISS]
- embryonic pattern specification [TAS]
- epithelial-mesenchymal signaling involved in prostate gland development [IDA]
- forebrain development [ISS]
- heart development [ISS]
- heart looping [ISS]
- hindbrain development [ISS]
- lung development [ISS]
- lymphoid progenitor cell differentiation [IMP]
- male genitalia development [ISS]
- metanephric mesenchymal cell proliferation involved in metanephros development [ISS]
- metanephros development [ISS]
- midbrain development [ISS]
- negative regulation of apoptotic process [ISS]
- negative regulation of cell differentiation [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of cholesterol efflux [ISS]
- negative regulation of kidney smooth muscle cell differentiation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- negative regulation of ureter smooth muscle cell differentiation [ISS]
- negative thymic T cell selection [ISS]
- neural crest cell migration [ISS]
- neuroblast proliferation [ISS]
- neuron fate commitment [ISS]
- pattern specification process [ISS]
- patterning of blood vessels [ISS]
- polarity specification of anterior/posterior axis [ISS]
- positive regulation of T cell differentiation in thymus [ISS]
- positive regulation of alpha-beta T cell differentiation [ISS]
- positive regulation of cell division [IDA]
- positive regulation of cell proliferation [IDA, ISS]
- positive regulation of hh target transcription factor activity [ISS]
- positive regulation of immature T cell proliferation in thymus [ISS]
- positive regulation of kidney smooth muscle cell differentiation [ISS]
- positive regulation of mesenchymal cell proliferation involved in ureter development [ISS]
- positive regulation of sclerotome development [IDA]
- positive regulation of smoothened signaling pathway [IDA, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of ureter smooth muscle cell differentiation [ISS]
- positive thymic T cell selection [ISS]
- prostate gland development [ISS]
- regulation of cell proliferation [ISS]
- regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry [NAS]
- regulation of odontogenesis [ISS]
- regulation of protein localization to nucleus [IDA]
- regulation of proteolysis [ISS]
- renal system development [IEP]
- smoothened signaling pathway [IEP, ISS]
- somite development [ISS]
- stem cell development [ISS]
- thymus development [ISS]
- vasculogenesis [ISS]
- ventral midline development [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
DERL2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Derlin2 facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum.
Endoplasmic reticulum-associated degradation (ERAD) is an important system that eliminates misfolded proteins from the ER. Three derlins have been implicated in this process, but their precise function remains unknown. In this study, we report that although both derlin1 and derlin2 are capable of binding the ERAD specific ubiquitin ligase HRD1, they associate with the HRD1-containing complex with different affinities. Accordingly, ... [more]
Throughput
- Low Throughput
Ontology Terms
- hek-293t cell (BTO:0002181)
Curated By
- BioGRID