SIPA1L1
Gene Ontology Biological Process
- actin cytoskeleton reorganization [IDA]
- activation of Rap GTPase activity [IDA]
- ephrin receptor signaling pathway [ISO, ISS]
- regulation of Rap GTPase activity [IDA, ISO, ISS]
- regulation of axonogenesis [ISO, ISS]
- regulation of dendrite morphogenesis [IMP]
- regulation of dendritic spine morphogenesis [IDA]
- regulation of synaptic plasticity [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Prenatal stress increased Snk Polo-like kinase 2, SCF β-TrCP ubiquitin ligase and ubiquitination of SPAR in the hippocampus of the offspring at adulthood.
Exposure to excessive glucocorticoids during fetal development period contributes to later life psychopathology. Prenatal stress decreases dendritic spine density and impair LTP in the hippocampus of rat pups, however, the mechanisms regulating these changes are still unclear. Glutamate receptors are localized in the postsynaptic density. PSD-95 is a postsynaptic scaffolding protein that plays a role in synaptic maturation and regulation ... [more]
Throughput
- Low Throughput
Additional Notes
- likely ubiquitin conjugate
Curated By
- BioGRID