PELI1
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- innate immune response [TAS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [TAS]
- toll-like receptor 10 signaling pathway [TAS]
- toll-like receptor 2 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor 5 signaling pathway [TAS]
- toll-like receptor 9 signaling pathway [TAS]
- toll-like receptor TLR1:TLR2 signaling pathway [TAS]
- toll-like receptor TLR6:TLR2 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
Gene Ontology Molecular Function
DEAF1
Gene Ontology Biological Process
- anatomical structure morphogenesis [TAS]
- embryonic skeletal system development [ISS]
- germ cell development [TAS]
- negative regulation of transcription, DNA-templated [IDA]
- neural tube closure [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of mammary gland epithelial cell proliferation [IDA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
DEAF1 is a Pellino1-interacting protein required for interferon production by Sendai virus and double stranded RNA.
Double-stranded (ds) RNA of viral origin, a ligand for Melanoma Differentiation Associated gene 5 (MDA5) and Toll-Like Receptor 3 (TLR3), induces the TANK-Binding Kinase 1 (TBK1) -dependent phosphorylation and activation of Interferon Regulatory Factor 3 (IRF3) and the E3 ubiquitin ligase Pellino1, which are required for interferon β (IFNβ) gene transcription. Here, we report that Pellino1 interacts with the transcription ... [more]
Throughput
- Low Throughput
Ontology Terms
- hek-293ft cell (BTO:0005029)
Curated By
- BioGRID