BAIT
NRP1
C530029I03, NP-1, NPN-1, Npn1, Nrp
neuropilin 1
GO Process (55)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [IMP]
- VEGF-activated neuropilin signaling pathway involved in axon guidance [IMP]
- angiogenesis [IGI, IMP, ISO]
- angiogenesis involved in coronary vascular morphogenesis [IMP]
- artery morphogenesis [IMP]
- axon extension involved in axon guidance [IMP]
- axon guidance [IDA, IMP, ISO]
- axonal fasciculation [IMP]
- axonogenesis involved in innervation [IMP]
- cell migration [IMP]
- cell migration involved in coronary vasculogenesis [IC]
- cell migration involved in sprouting angiogenesis [IC, IMP]
- cellular response to hepatocyte growth factor stimulus [ISO]
- cellular response to vascular endothelial growth factor stimulus [IMP]
- commissural neuron axon guidance [IMP]
- coronary artery morphogenesis [IMP]
- dendrite development [IMP]
- dichotomous subdivision of terminal units involved in salivary gland branching [IGI, IMP]
- endothelial cell chemotaxis [ISO]
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus [IMP]
- heart development [IGI]
- hepatocyte growth factor receptor signaling pathway [ISO]
- negative regulation of axon extension [IGI]
- negative regulation of axon extension involved in axon guidance [IDA, ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of neuron apoptotic process [IMP]
- nerve development [IMP]
- neural crest cell migration involved in autonomic nervous system development [IMP]
- neuron development [IMP]
- neuron migration [IMP]
- patterning of blood vessels [IMP]
- peptidyl-tyrosine phosphorylation [IMP]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive chemotaxis [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of axon extension involved in axon guidance [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP, ISO]
- positive regulation of retinal ganglion cell axon guidance [IMP]
- protein localization to early endosome [IMP]
- regulation of axon extension involved in axon guidance [IDA]
- regulation of retinal ganglion cell axon guidance [IMP]
- renal artery morphogenesis [IMP]
- retina vasculature morphogenesis in camera-type eye [IMP]
- retinal ganglion cell axon guidance [IMP]
- semaphorin-plexin signaling pathway [IDA, IGI, IPI]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [IMP]
- sprouting angiogenesis [IMP]
- sympathetic ganglion development [IMP]
- sympathetic nervous system development [IMP]
- sympathetic neuron projection extension [IMP]
- sympathetic neuron projection guidance [IMP]
- toxin transport [IMP]
- trigeminal nerve morphogenesis [IMP]
- vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
- vascular endothelial growth factor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SEMA3A
Hsema-I, SEMA1, SemD, Semad, coll-1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
GO Process (26)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- apoptotic process [ISO]
- axon extension involved in axon guidance [IMP]
- axon guidance [IDA, IMP, ISO]
- axonal fasciculation [IMP]
- axonogenesis involved in innervation [IMP]
- dendrite morphogenesis [IMP]
- dichotomous subdivision of terminal units involved in salivary gland branching [IDA, IGI]
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus [IMP]
- negative chemotaxis [IDA, IGI]
- negative regulation of axon extension [IDA, IGI, ISO]
- negative regulation of axon extension involved in axon guidance [IDA, IGI]
- negative regulation of epithelial cell migration [IDA]
- nerve development [IMP]
- neural crest cell migration involved in autonomic nervous system development [IMP]
- neural crest cell migration involved in sympathetic nervous system development [IMP]
- neuron migration [IMP]
- olfactory bulb development [ISO]
- positive regulation of male gonad development [IMP]
- positive regulation of neuron migration [IGI]
- regulation of axon extension involved in axon guidance [IDA, ISO]
- regulation of heart rate [IMP]
- semaphorin-plexin signaling pathway [IGI]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [IMP]
- sympathetic ganglion development [IMP]
- sympathetic neuron projection extension [IMP]
- sympathetic neuron projection guidance [IMP]
Gene Ontology Molecular Function
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Co-receptors add complexity to cell-cell signaling systems. The secreted semaphorin 3s (Sema3s) require a co-receptor, neuropilin (Nrp), to signal through plexin As (PlxnAs) in functions ranging from axon guidance to bone homeostasis, but the role of the co-receptor is obscure. Here we present the low-resolution crystal structure of a mouse semaphorin-plexin-Nrp complex alongside unliganded component structures. Dimeric semaphorin, two copies ... [more]
Nat. Struct. Mol. Biol. Dec. 01, 2012; 19(12);1293-9 [Pubmed: 23104057]
Throughput
- Low Throughput
Additional Notes
- surface plasmon resonance (SPR) assays
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SEMA3A NRP1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | High | - | BioGRID | 2549822 | |
| NRP1 SEMA3A | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | High | - | BioGRID | 2549840 |
Curated By
- BioGRID