BAIT
NRP1
C530029I03, NP-1, NPN-1, Npn1, Nrp
neuropilin 1
GO Process (55)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [IMP]
- VEGF-activated neuropilin signaling pathway involved in axon guidance [IMP]
- angiogenesis [IGI, IMP, ISO]
- angiogenesis involved in coronary vascular morphogenesis [IMP]
- artery morphogenesis [IMP]
- axon extension involved in axon guidance [IMP]
- axon guidance [IDA, IMP, ISO]
- axonal fasciculation [IMP]
- axonogenesis involved in innervation [IMP]
- cell migration [IMP]
- cell migration involved in coronary vasculogenesis [IC]
- cell migration involved in sprouting angiogenesis [IC, IMP]
- cellular response to hepatocyte growth factor stimulus [ISO]
- cellular response to vascular endothelial growth factor stimulus [IMP]
- commissural neuron axon guidance [IMP]
- coronary artery morphogenesis [IMP]
- dendrite development [IMP]
- dichotomous subdivision of terminal units involved in salivary gland branching [IGI, IMP]
- endothelial cell chemotaxis [ISO]
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus [IMP]
- heart development [IGI]
- hepatocyte growth factor receptor signaling pathway [ISO]
- negative regulation of axon extension [IGI]
- negative regulation of axon extension involved in axon guidance [IDA, ISO]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- negative regulation of neuron apoptotic process [IMP]
- nerve development [IMP]
- neural crest cell migration involved in autonomic nervous system development [IMP]
- neuron development [IMP]
- neuron migration [IMP]
- patterning of blood vessels [IMP]
- peptidyl-tyrosine phosphorylation [IMP]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive chemotaxis [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of axon extension involved in axon guidance [IMP]
- positive regulation of peptidyl-tyrosine phosphorylation [IMP, ISO]
- positive regulation of retinal ganglion cell axon guidance [IMP]
- protein localization to early endosome [IMP]
- regulation of axon extension involved in axon guidance [IDA]
- regulation of retinal ganglion cell axon guidance [IMP]
- renal artery morphogenesis [IMP]
- retina vasculature morphogenesis in camera-type eye [IMP]
- retinal ganglion cell axon guidance [IMP]
- semaphorin-plexin signaling pathway [IDA, IGI, IPI]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [IMP]
- sprouting angiogenesis [IMP]
- sympathetic ganglion development [IMP]
- sympathetic nervous system development [IMP]
- sympathetic neuron projection extension [IMP]
- sympathetic neuron projection guidance [IMP]
- toxin transport [IMP]
- trigeminal nerve morphogenesis [IMP]
- vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
- vascular endothelial growth factor signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PLXNA2
2810428A13Rik, AA589422, AW457381, OCT, PlexA2, Plxn2, mKIAA0463
plexin A2
GO Process (5)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex.
Co-receptors add complexity to cell-cell signaling systems. The secreted semaphorin 3s (Sema3s) require a co-receptor, neuropilin (Nrp), to signal through plexin As (PlxnAs) in functions ranging from axon guidance to bone homeostasis, but the role of the co-receptor is obscure. Here we present the low-resolution crystal structure of a mouse semaphorin-plexin-Nrp complex alongside unliganded component structures. Dimeric semaphorin, two copies ... [more]
Nat. Struct. Mol. Biol. Dec. 01, 2012; 19(12);1293-9 [Pubmed: 23104057]
Throughput
- Low Throughput
Additional Notes
- surface plasmon resonance (SPR) assays
Curated By
- BioGRID