BAIT

RBX1

BA554C12.1, RNF75, ROC1, RP11-554C12.1
ring-box 1, E3 ubiquitin protein ligase
Cell Cycle - Senescence Project
Fanconi Anemia Project
UPS Project
Homo sapiens
PREY

TRIM74

TRIM50C
tripartite motif containing 74
UPS Project
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks.

Woodsmith J, Jenn RC, Sanderson CM

Ubiquitination controls the stability or function of many human proteins, thereby regulating a wide range of physiological processes. In most cases the combinatorial pattern of protein interactions that facilitate substrate recognition or modification remain unclear. Moreover, the efficiency of ubiquitination reactions can be altered by the formation of homo- and heterotypic E3-RING complexes. To establish the prevalence and nature of ... [more]

Unknown Apr. 11, 2012; 0(0); [Pubmed: 22493164]

Throughput

  • High Throughput

Curated By

  • BioGRID