BAIT

MRF1

SPAC2F7.17, SPAC2F7.17
mitochondrial peptide chain release factor (predicted)
GO Process (1)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

PTH4

mug82, SPAC589.11
mitochondrial translation release factor
GO Process (1)
GO Function (0)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Interactions between peptidyl tRNA hydrolase homologs and the ribosomal release factor Mrf1 in S. pombe mitochondria.

Dujeancourt L, Richter R, Chrzanowska-Lightowlers ZM, Bonnefoy N, Herbert CJ

Mitochondrial translation synthesizes key subunits of the respiratory complexes. In Schizosaccharomyces pombe, strains lacking Mrf1, the mitochondrial stop codon recognition factor, are viable, suggesting that other factors can play a role in translation termination. S. pombe contains four predicted peptidyl tRNA hydrolases, two of which (Pth3 and Pth4), have a GGQ motif that is conserved in class I release factors. ... [more]

Mitochondrion Jul. 24, 2013; 0(0); [Pubmed: 23892058]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: respiratory growth (APO:0000309)

Additional Notes

  • over-expression of pth4 significantly improves the respiratory growth of the mrf1D strain

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
MRF1 PTH4
Synthetic Lethality
Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Low-BioGRID
884921

Curated By

  • BioGRID