BAIT

DCD1

SPBC2G2.13c, SPBC2G2.13c
deoxycytidylate deaminase (predicted)
GO Process (2)
GO Function (1)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Schizosaccharomyces pombe (972h)
PREY

MRC1

SPAC694.06c
mediator of replication checkpoint 1
Schizosaccharomyces pombe (972h)

Synthetic Lethality

A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

Replication Fork Collapse and Genome Instability in dCMP Deaminase Mutant.

Sanchez A, Sharma S, Rozenzhak S, Roguev A, Krogan NJ, Chabes A, Russell P

Ribonucleotide reductase (RNR) and deoxycytidylate deaminase (dCMP deaminase) are pivotal allosteric enzymes required to maintain adequate pools of deoxyribonucleoside triphosphates (dNTPs) for DNA synthesis and repair. Whereas RNR inhibition slows DNA replication and activates checkpoint responses, the effect of dCMP deaminase deficiency is largely unknown. Here, we report that deleting the Schizosaccharomyces pombe dcd1(+) dCMP deaminase gene (SPBC2G2.13c) increases dCTP ... [more]

Mol. Cell. Biol. Aug. 27, 2012; 0(0); [Pubmed: 22927644]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: resistance to chemicals (APO:0000087)
  • phenotype: inviable (APO:0000112)

Additional Notes

  • double mutants show increased sensitivity to DNA damaging agents

Curated By

  • BioGRID