BAIT
VEGFA
VEGF-A, VEGF164, VPF, Vegf
vascular endothelial growth factor A
GO Process (132)
GO Function (16)
GO Component (7)
Gene Ontology Biological Process
- T-helper 1 type immune response [IDA]
- VEGF-activated neuropilin signaling pathway [ISO]
- activation of protein kinase activity [ISO]
- aging [IEP]
- angiogenesis [IMP, ISO, TAS]
- angiogenesis involved in coronary vascular morphogenesis [IMP]
- artery morphogenesis [ISO]
- basophil chemotaxis [ISO]
- blood vessel development [ISO]
- blood vessel morphogenesis [ISO]
- blood vessel remodeling [IMP]
- branching morphogenesis of an epithelial tube [ISO]
- camera-type eye morphogenesis [ISO]
- cardiac muscle fiber development [ISO]
- cardiac vascular smooth muscle cell development [ISO]
- cell chemotaxis [IMP]
- cell maturation [ISO]
- cell migration [ISO]
- cell migration involved in sprouting angiogenesis [ISO]
- cell proliferation [ISO]
- cellular response to dexamethasone stimulus [IEP]
- cellular response to drug [IEP]
- cellular response to fibroblast growth factor stimulus [IEP]
- cellular response to hypoxia [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- commissural neuron axon guidance [ISO]
- coronary artery morphogenesis [ISO]
- coronary vein morphogenesis [ISO]
- dopaminergic neuron differentiation [ISO]
- endothelial cell chemotaxis [ISO]
- endothelial cell migration [ISO]
- epithelial cell differentiation [ISO]
- eye photoreceptor cell development [ISO]
- female pregnancy [IEP]
- growth [ISO]
- heart morphogenesis [ISO]
- hyaluronan metabolic process [IEP]
- in utero embryonic development [ISO]
- induction of positive chemotaxis [ISO]
- kidney development [ISO]
- lactation [ISO]
- lung alveolus development [IMP]
- lung development [ISO]
- lung vasculature development [ISO]
- lymph vessel morphogenesis [ISO]
- mRNA stabilization [IDA]
- macrophage differentiation [ISO]
- mammary gland alveolus development [ISO]
- mesoderm development [ISO]
- monocyte differentiation [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of bone resorption [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of neuron death [IMP]
- negative regulation of programmed cell death [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- nervous system development [IDA, NAS]
- neuron development [ISO]
- outflow tract morphogenesis [ISO]
- ovarian follicle development [ISO]
- patterning of blood vessels [ISO]
- positive chemotaxis [IMP, ISO]
- positive regulation of CREB transcription factor activity [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of angiogenesis [IDA, ISO, ISS]
- positive regulation of axon extension involved in axon guidance [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of branching involved in ureteric bud morphogenesis [ISO]
- positive regulation of cell adhesion [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell migration involved in sprouting angiogenesis [ISO]
- positive regulation of cell proliferation [IMP, ISO, TAS]
- positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway [ISO]
- positive regulation of cellular component movement [ISO]
- positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway [ISO]
- positive regulation of endothelial cell migration [ISO, ISS]
- positive regulation of endothelial cell proliferation [ISO, ISS]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of focal adhesion assembly [ISO, ISS]
- positive regulation of gene expression [ISO]
- positive regulation of histone deacetylase activity [ISO]
- positive regulation of lymphangiogenesis [ISO]
- positive regulation of mast cell chemotaxis [ISO]
- positive regulation of mesenchymal cell proliferation [ISO]
- positive regulation of neuroblast proliferation [ISO]
- positive regulation of p38MAPK cascade [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of peptidyl-tyrosine autophosphorylation [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO, ISS]
- positive regulation of positive chemotaxis [ISO]
- positive regulation of protein autophosphorylation [ISO]
- positive regulation of protein complex assembly [ISO, ISS]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of protein kinase C signaling [ISO]
- positive regulation of protein kinase D signaling [ISO]
- positive regulation of protein localization to early endosome [ISO]
- positive regulation of protein phosphorylation [ISO, ISS]
- positive regulation of receptor internalization [ISO]
- positive regulation of retinal ganglion cell axon guidance [ISO]
- positive regulation of signal transduction [IDA]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [ISO]
- positive regulation of vascular endothelial growth factor receptor signaling pathway [ISO]
- positive regulation of vascular permeability [IMP, ISO]
- post-embryonic camera-type eye development [ISO]
- primitive erythrocyte differentiation [ISO]
- regulation of cGMP metabolic process [ISO]
- regulation of cell shape [ISO]
- regulation of endothelial cell differentiation [ISO]
- regulation of hematopoietic progenitor cell differentiation [ISO]
- regulation of retinal ganglion cell axon guidance [ISO]
- regulation of transcription from RNA polymerase II promoter [ISO]
- response to cold [IEP]
- response to dexamethasone [IEP]
- response to estradiol [IEP]
- response to folic acid [IEP]
- response to hypoxia [IDA, ISO]
- response to oxygen levels [IEP]
- response to progesterone [IEP]
- response to vitamin A [IEP]
- sprouting angiogenesis [ISO]
- surfactant homeostasis [ISO]
- tube formation [ISO, ISS]
- vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
- vascular endothelial growth factor signaling pathway [ISO]
- vasculature development [ISO]
- wound healing [IEP]
Gene Ontology Molecular Function- chemoattractant activity [IMP, ISO]
- cytokine activity [ISO]
- extracellular matrix binding [ISO]
- fibronectin binding [ISO]
- growth factor activity [IDA, ISO]
- heparin binding [ISO]
- identical protein binding [ISO]
- neuropilin binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [IDA]
- receptor agonist activity [ISO]
- receptor binding [ISO]
- vascular endothelial growth factor receptor 1 binding [ISO]
- vascular endothelial growth factor receptor 2 binding [IMP, ISO]
- vascular endothelial growth factor receptor binding [ISO, TAS]
- chemoattractant activity [IMP, ISO]
- cytokine activity [ISO]
- extracellular matrix binding [ISO]
- fibronectin binding [ISO]
- growth factor activity [IDA, ISO]
- heparin binding [ISO]
- identical protein binding [ISO]
- neuropilin binding [ISO]
- platelet-derived growth factor receptor binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [IDA]
- receptor agonist activity [ISO]
- receptor binding [ISO]
- vascular endothelial growth factor receptor 1 binding [ISO]
- vascular endothelial growth factor receptor 2 binding [IMP, ISO]
- vascular endothelial growth factor receptor binding [ISO, TAS]
Gene Ontology Cellular Component
Rattus norvegicus
PREY
NRP1
Nrp
neuropilin 1
GO Process (55)
GO Function (5)
GO Component (12)
Gene Ontology Biological Process
- VEGF-activated neuropilin signaling pathway [ISO]
- VEGF-activated neuropilin signaling pathway involved in axon guidance [ISO]
- angiogenesis [ISO]
- angiogenesis involved in coronary vascular morphogenesis [ISO]
- artery morphogenesis [ISO]
- axon extension involved in axon guidance [ISO]
- axon guidance [IMP, ISO]
- axonal fasciculation [ISO]
- axonogenesis involved in innervation [ISO]
- cell migration [ISO]
- cell migration involved in sprouting angiogenesis [ISO]
- cellular response to hepatocyte growth factor stimulus [ISO]
- cellular response to vascular endothelial growth factor stimulus [ISO]
- commissural neuron axon guidance [ISO]
- coronary artery morphogenesis [ISO]
- dendrite development [ISO]
- dichotomous subdivision of terminal units involved in salivary gland branching [ISO]
- endothelial cell chemotaxis [ISO]
- gonadotrophin-releasing hormone neuronal migration to the hypothalamus [ISO]
- heart development [ISO]
- hepatocyte growth factor receptor signaling pathway [ISO]
- negative regulation of axon extension [ISO]
- negative regulation of axon extension involved in axon guidance [IMP, ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of neuron apoptotic process [ISO]
- nerve development [ISO]
- nervous system development [NAS]
- neural crest cell migration involved in autonomic nervous system development [ISO]
- neuron development [ISO]
- neuron migration [ISO]
- patterning of blood vessels [ISO]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet-derived growth factor receptor signaling pathway [ISO]
- positive chemotaxis [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of axon extension involved in axon guidance [ISO]
- positive regulation of peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of retinal ganglion cell axon guidance [ISO]
- protein localization to early endosome [ISO]
- regulation of axon extension involved in axon guidance [ISO]
- regulation of retinal ganglion cell axon guidance [ISO]
- renal artery morphogenesis [ISO]
- response to wounding [IEP]
- retina vasculature morphogenesis in camera-type eye [ISO]
- retinal ganglion cell axon guidance [ISO]
- semaphorin-plexin signaling pathway [ISO]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [ISO]
- sprouting angiogenesis [ISO]
- sympathetic ganglion development [ISO]
- sympathetic nervous system development [ISO]
- sympathetic neuron projection extension [ISO]
- sympathetic neuron projection guidance [ISO]
- toxin transport [ISO]
- trigeminal nerve morphogenesis [ISO]
- vascular endothelial growth factor receptor signaling pathway [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Structure-function analysis of the antiangiogenic ATWLPPR peptide inhibiting VEGF(165) binding to neuropilin-1 and molecular dynamics simulations of the ATWLPPR/neuropilin-1 complex.
Heptapeptide ATWLPPR (A7R), identified in our laboratory by screening a mutated phage library, was shown to bind specifically to neuropilin-1 (NRP-1) and then to selectively inhibit VEGF(165) binding to this receptor. In vivo, treatment with A7R resulted in decreasing breast cancer angiogenesis and growth. The present work is focused on structural characterization of A7R. Analogs of the peptide, obtained by ... [more]
Peptides Dec. 01, 2007; 28(12);2397-402 [Pubmed: 17983687]
Throughput
- Low Throughput
Additional Notes
- interaction inhibited by heptapeptide ATWLPPR
Curated By
- BioGRID