BAIT
PLA2G4A
Pla2g4, cPLA2, cPLA2alpha
phospholipase A2, group IVA (cytosolic, calcium-dependent)
GO Process (15)
GO Function (5)
GO Component (8)
Gene Ontology Biological Process
- arachidonic acid metabolic process [ISO]
- arachidonic acid secretion [IDA, IMP]
- cellular response to antibiotic [IDA]
- decidualization [ISO]
- icosanoid biosynthetic process [IMP]
- ovulation from ovarian follicle [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of inflammatory response [ISO]
- positive regulation of prostaglandin biosynthetic process [ISO]
- positive regulation of vesicle fusion [ISO]
- regulation of cell proliferation [IGI]
- response to calcium ion [ISO]
- response to organic substance [ISO]
- surfactant homeostasis [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
VIM
RP23-185P20.1
vimentin
GO Process (11)
GO Function (12)
GO Component (16)
Gene Ontology Biological Process
- Bergmann glial cell differentiation [IMP]
- SMAD protein signal transduction [IDA]
- astrocyte development [IGI]
- intermediate filament organization [IGI]
- intermediate filament-based process [IMP]
- lens fiber cell development [IDA]
- negative regulation of neuron projection development [IGI]
- positive regulation of gene expression [IMP]
- positive regulation of glial cell proliferation [ISO]
- regulation of Schwann cell migration [ISO]
- regulation of axonogenesis [ISO]
Gene Ontology Molecular Function- double-stranded RNA binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- scaffold protein binding [ISO]
- structural constituent of cytoskeleton [ISO]
- structural constituent of eye lens [IDA]
- structural molecule activity [IMP]
- double-stranded RNA binding [ISO]
- glycoprotein binding [ISO]
- identical protein binding [ISO]
- kinase binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- protein phosphatase 2A binding [ISO]
- scaffold protein binding [ISO]
- structural constituent of cytoskeleton [ISO]
- structural constituent of eye lens [IDA]
- structural molecule activity [IMP]
Gene Ontology Cellular Component
- axon [ISO]
- cell body [ISO]
- cell leading edge [IDA]
- cell projection [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytoskeleton [ISO]
- cytosol [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- intermediate filament [IDA, ISO]
- intermediate filament cytoskeleton [ISO]
- neuron projection [IDA]
- perinuclear region of cytoplasm [ISO]
- peroxisome [ISO]
- plasma membrane [IDA, ISO]
- type III intermediate filament [TAS]
Mus musculus
Far Western
An interaction is detected between a protein immobilized on a membrane and a purified protein probe.
Publication
Identification of a cellular protein that functionally interacts with the C2 domain of cytosolic phospholipase A(2)alpha.
Cytosolic phospholipase A(2) (cPLA(2)) alpha plays critical roles in lipid mediator synthesis. We performed far-Western analysis and identified a 60-kDa protein (P60) that interacted with cPLA(2)alpha in a Ca(2+)-dependent manner. Peptide microsequencing revealed that purified P60 was identical to vimentin, a major component of the intermediate filament. The interaction occurred between the C2 domain of cPLA(2)alpha and the head domain ... [more]
J. Biol. Chem. Jan. 14, 2000; 275(2);1161-8 [Pubmed: 10625659]
Throughput
- Low Throughput
Curated By
- BioGRID