FBXO25
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ADRBK1
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISS]
- activation of phospholipase C activity [TAS]
- cardiac muscle contraction [IMP]
- desensitization of G-protein coupled receptor protein signaling pathway [ISS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of striated muscle contraction [IMP]
- negative regulation of the force of heart contraction by chemical signal [IMP]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-serine phosphorylation [ISS]
- positive regulation of catecholamine secretion [ISS]
- receptor internalization [IDA]
- signal transduction [TAS]
- tachykinin receptor signaling pathway [IDA]
Gene Ontology Molecular Function
Biochemical Activity (Ubiquitination)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
The F-box protein FBXO25 promotes the proteasome-dependent degradation of ELK-1.
FBXO25 is one of the sixty-nine known human F-box proteins that serve as specificity factors for a family of ubiquitin ligases composed of SKP1, Rbx1, Cullin1 and F-box protein (SCF1) that are involved in targeting proteins for degradation across the ubiquitin proteasome system (UPS). However, the substrates of most SCF E3 ligases remain unknown. Here, we applied an in chip ... [more]
Throughput
- High Throughput
Ontology Terms
- cell type: hek-293t cell (BTO:0002181)
Additional Notes
- The reactions were prepared as following purified SCF1FBXO25 or SCF1FBXO25 Fbox and 100 ng E1 , 500 ng E2 UbcH5c or 500 ng E2DN
- To identify FBXO25 substrate candidates, we have used the human protoarray as target and the purified SCF1FBXO25 complexes as a source of E3 ligases. putative substrates of FBXO25 were identified with high confidence
Curated By
- BioGRID