YOR1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RCF2
Gene Ontology Biological Process
Gene Ontology Cellular Component
Positive Genetic
Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a less severe fitness defect than expected under a given condition. This term is reserved for high or low throughput studies with scores.
Publication
A yeast phenomic model for the gene interaction network modulating CFTR-ΔF508 protein biogenesis.
BACKGROUND: The overall influence of gene interaction in human disease is unknown. In cystic fibrosis (CF) a single allele of the cystic fibrosis transmembrane conductance regulator (CFTR-ΔF508) accounts for most of the disease. In cell models, CFTR-ΔF508 exhibits defective protein biogenesis and degradation rather than proper trafficking to the plasma membrane where CFTR normally functions. Numerous genes function in the ... [more]
Throughput
- High Throughput
Ontology Terms
- phenotype: resistance to chemicals (APO:0000087)
Additional Notes
- oligomycin
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
RCF2 YOR1 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -0.1464 | BioGRID | 2176836 |
Curated By
- BioGRID