Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2.

Kanno K, Wu MK, Agate DS, Fanelli BJ, Wagle N, Scapa EF, Ukomadu C, Cohen DE

The Star (steroidogenic acute regulatory protein)-related transfer (START) domain superfamily is characterized by a distinctive lipid-binding motif. START domains typically reside in multidomain proteins, suggesting their function as lipid sensors that trigger biological activities. Phosphatidylcholine transfer protein (PC-TP, also known as StarD2) is an example of a START domain minimal protein that consists only of the lipid-binding motif. PC-TP, which ... [more]

J. Biol. Chem. Oct. 19, 2007; 282(42);30728-36 [Pubmed: 17704541]

Throughput

Low Throughput

Ontology Terms

tissue: liver (BTO:0000759)
tissue: liver (UBERON:0002107)

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
PCTP ACOT13	Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro.	Kanno K (2007)	Low	-	BioGRID	-

Curated By

BioGRID

Interaction Summary

PCTP

Gene Ontology Biological Process

Gene Ontology Molecular Function

phosphatidylcholine binding [ISO]phosphatidylcholine transporter activity [ISO]

ACOT13

Gene Ontology Biological Process

Gene Ontology Molecular Function

acyl-CoA hydrolase activity [ISO]

Gene Ontology Cellular Component

Two-hybrid