TEC
Gene Ontology Biological Process
- B cell receptor signaling pathway [IBA, ISO]
- T cell receptor signaling pathway [IBA]
- adaptive immune response [IBA]
- cell differentiation [IBA]
- innate immune response [IBA]
- integrin-mediated signaling pathway [IBA, ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- regulation of cell proliferation [IBA]
- regulation of platelet activation [IBA, ISO]
- tissue regeneration [IBA]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PLCG1
Gene Ontology Biological Process
- T cell receptor signaling pathway [IDA]
- calcium ion transport [ISO]
- calcium-mediated signaling [ISO]
- cell migration [ISO]
- cellular response to epidermal growth factor stimulus [ISO]
- epidermal growth factor receptor signaling pathway [ISO]
- in utero embryonic development [IMP]
- inositol trisphosphate biosynthetic process [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of blood vessel endothelial cell migration [ISO]
- positive regulation of epithelial cell migration [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- protein secretion [ISO]
- regulation of store-operated calcium channel activity [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Mediation by the protein-tyrosine kinase Tec of signaling between the B cell antigen receptor and Dok-1.
A variety of growth factor receptors induce the tyrosine phosphorylation of a nonreceptor protein-tyrosine kinase Tec as well as that of a Tec-binding protein of 62 kDa. Given the similarity in properties between this 62-kDa protein and p62(Dok-1), the possibility that these two proteins are identical was investigated. Overexpression of a constitutively active form of Tec in a pro-B cell ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID