BAIT
CDC25
sal2, SPAC24H6.05
M phase inducer tyrosine phosphatase Cdc25
GO Process (6)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- mitotic DNA replication checkpoint [IMP]
- peptidyl-tyrosine dephosphorylation involved in activation of protein kinase activity [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle [IMP]
- regulation of G2/M transition of mitotic cell cycle [IMP]
- regulation of cell size [NAS]
- signal transduction involved in intra-S DNA damage checkpoint [IMP]
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
PREY
DNT1
SPBC25D12.02c
nucleolar protein Dnt1
GO Process (5)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
- chromatin silencing at rDNA [IMP]
- negative regulation of protein localization to mitotic spindle pole body [IMP]
- negative regulation of septation initiation signaling [IGI]
- negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle [IMP]
- positive regulation of G2/M transition of mitotic cell cycle [IMP]
Gene Ontology Molecular Function
Schizosaccharomyces pombe (972h)
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
Fission yeast nucleolar protein Dnt1 regulates G2/M transition and cytokinesis through downregulating Wee1 kinase.
Cytokinesis involves temporally and spatially coordinated action of the cell cycle, cytoskeletal and membrane systems to achieve separation of daughter cells. The septation initiation network (SIN) and mitotic exit network (MEN) signaling pathways regulate cytokinesis and mitotic exit in the yeasts Schizosaccharomyces pombe and Saccharomyces cerevisiae, respectively. Previously, we have shown that in fission yeast the nucleolar protein Dnt1 negatively ... [more]
J. Cell. Sci. Sep. 04, 2013; 0(0); [Pubmed: 24006256]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112) [temperature sensitive growth (APO:0000092)]
Additional Notes
- dnt1D deletion is synthetic lethal with cdc25D
Curated By
- BioGRID