BAIT
SNTA1
LQT12, SNT1, TACIP1, dJ1187J4.5
syntrophin, alpha 1
GO Process (6)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
STAM
STAM-1, STAM1
signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
GO Process (8)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- endosomal transport [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- membrane organization [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- positive regulation of exosomal secretion [IMP]
- positive regulation of signal transduction [TAS]
- regulation of extracellular vesicular exosome assembly [IMP]
- signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.
Hypertension is a cardiovascular disease associated with increased plasma catecholamines, overactivation of the sympathetic nervous system, and increased vascular tone and total peripheral resistance. A key regulator of sympathetic nervous system function is the alpha(1D)-adrenergic receptor (AR), which belongs to the adrenergic family of G-protein-coupled receptors (GPCRs). Endogenous catecholamines norepinephrine and epinephrine activate alpha(1D)-ARs on vascular smooth muscle to stimulate ... [more]
J. Biol. Chem. Jul. 04, 2008; 283(27);18792-800 [Pubmed: 18468998]
Throughput
- Low Throughput
Ontology Terms
- cell line: hek-293 cell (BTO:0000007) [epithelial cell (CL:0000066)]
Additional Notes
- exogenous expression of bait
Curated By
- BioGRID