BAIT
ADRA1D
ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2
adrenoceptor alpha 1D
GO Process (8)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
- DNA metabolic process [TAS]
- G-protein coupled receptor signaling pathway [TAS]
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway [TAS]
- adrenergic receptor signaling pathway [TAS]
- cell proliferation [TAS]
- cell-cell signaling [TAS]
- multicellular organismal development [TAS]
- positive regulation of cell proliferation [TAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
CKAP4
CLIMP-63, ERGIC-63, p63
cytoskeleton-associated protein 4
GO Process (0)
GO Function (1)
GO Component (3)
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Blood pressure is regulated by an alpha1D-adrenergic receptor/dystrophin signalosome.
Hypertension is a cardiovascular disease associated with increased plasma catecholamines, overactivation of the sympathetic nervous system, and increased vascular tone and total peripheral resistance. A key regulator of sympathetic nervous system function is the alpha(1D)-adrenergic receptor (AR), which belongs to the adrenergic family of G-protein-coupled receptors (GPCRs). Endogenous catecholamines norepinephrine and epinephrine activate alpha(1D)-ARs on vascular smooth muscle to stimulate ... [more]
J. Biol. Chem. Jul. 04, 2008; 283(27);18792-800 [Pubmed: 18468998]
Throughput
- Low Throughput
Ontology Terms
- cell line: hek-293 cell (BTO:0000007) [epithelial cell (CL:0000066)]
Additional Notes
- exogenous expression of bait
Curated By
- BioGRID