PIK3R1
Gene Ontology Biological Process
- B cell differentiation [ISO]
- NFAT protein import into nucleus [ISO]
- aging [IEP]
- cellular glucose homeostasis [ISO, ISS]
- cellular response to UV [ISO]
- cellular response to fatty acid [IEP]
- cellular response to insulin stimulus [IEP, ISO, ISS]
- extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- glucose metabolic process [IMP]
- growth hormone receptor signaling pathway [ISO]
- insulin receptor signaling pathway [IMP, ISS]
- insulin-like growth factor receptor signaling pathway [IMP, ISO, ISS]
- intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- negative regulation of apoptotic process [ISO, ISS]
- negative regulation of blood pressure [IMP]
- negative regulation of cell-cell adhesion [IMP]
- negative regulation of cell-matrix adhesion [ISO]
- negative regulation of heart rate [IMP]
- negative regulation of muscle cell apoptotic process [IMP]
- negative regulation of osteoclast differentiation [ISO]
- negative regulation of proteolysis [IMP]
- negative regulation of smooth muscle cell proliferation [IMP]
- phosphatidylinositol 3-kinase signaling [ISO]
- phosphatidylinositol phosphorylation [ISS]
- phosphatidylinositol-3-phosphate biosynthetic process [IDA, TAS]
- positive regulation of RNA splicing [ISO, ISS]
- positive regulation of cell migration [IMP, ISO]
- positive regulation of endoplasmic reticulum unfolded protein response [ISO, ISS]
- positive regulation of gene expression [IMP]
- positive regulation of myoblast differentiation [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of transcription factor import into nucleus [ISO, ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISO, ISS]
- positive regulation of tumor necrosis factor production [ISO]
- protein phosphorylation [ISO]
- protein stabilization [ISO, ISS]
- regulation of phosphatidylinositol 3-kinase activity [IDA]
- response to amino acid [IEP]
- response to cAMP [IDA]
- response to dexamethasone [IEP]
- response to drug [IEP]
- response to endoplasmic reticulum stress [ISO, ISS]
- response to estradiol [IEP]
- response to ethanol [IEP]
- response to fatty acid [IEP]
- response to fructose [IEP]
- response to glucocorticoid [IDA]
- response to growth factor [IEP]
- response to insulin [IDA]
- response to iron(II) ion [IEP]
- response to nutrient [IEP]
- response to progesterone [IEP]
- response to testosterone [IEP]
- response to yeast [IEP]
Gene Ontology Molecular Function- 1-phosphatidylinositol-3-kinase activity [IDA, TAS]
- 1-phosphatidylinositol-3-kinase regulator activity [IDA]
- ATPase binding [IPI]
- ErbB-3 class receptor binding [ISO, ISS]
- calmodulin binding [IPI]
- estrogen receptor binding [IPI]
- insulin binding [ISO]
- insulin receptor binding [ISO, ISS]
- insulin receptor substrate binding [IPI, ISO, ISS]
- insulin-like growth factor receptor binding [ISO, ISS]
- neurotrophin TRKA receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [IPI]
- phosphatidylinositol 3-kinase regulator activity [ISS]
- phosphoprotein binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein C-terminus binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- receptor binding [IPI]
- receptor tyrosine kinase binding [IPI]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [IPI]
- 1-phosphatidylinositol-3-kinase activity [IDA, TAS]
- 1-phosphatidylinositol-3-kinase regulator activity [IDA]
- ATPase binding [IPI]
- ErbB-3 class receptor binding [ISO, ISS]
- calmodulin binding [IPI]
- estrogen receptor binding [IPI]
- insulin binding [ISO]
- insulin receptor binding [ISO, ISS]
- insulin receptor substrate binding [IPI, ISO, ISS]
- insulin-like growth factor receptor binding [ISO, ISS]
- neurotrophin TRKA receptor binding [ISO]
- phosphatidylinositol 3-kinase binding [IPI]
- phosphatidylinositol 3-kinase regulator activity [ISS]
- phosphoprotein binding [IPI]
- platelet-derived growth factor receptor binding [IPI]
- protein C-terminus binding [IDA]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- receptor binding [IPI]
- receptor tyrosine kinase binding [IPI]
- transcription factor binding [ISO]
- ubiquitin protein ligase binding [IPI]
Gene Ontology Cellular Component
IRS3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Characterization of insulin receptor substrate 3 in rat liver derived cells.
In rat liver derived HTC cells transfected with and expressing human insulin receptors, there are multiple p60-70 proteins that are tyrosine phosphorylated following insulin treatment of cells. Employing antibodies to insulin receptor substrate 3 (alpha-IRS-3), we found that IRS-3 is a major p60 phosphoprotein that is tyrosine phosphorylated following insulin treatment of cells and interacts with phosphatidylinositol-3-kinase (PI3K). Majority of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IRS3 PIK3R1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID