HNRNPA0
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CXCL2
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IBA]
- cell chemotaxis [IBA]
- chemokine-mediated signaling pathway [IBA]
- immune response [IBA]
- inflammatory response [IBA]
- leukocyte chemotaxis [ISO]
- neuron death [ISO]
- neutrophil chemotaxis [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of leukocyte chemotaxis [IBA]
- regulation of cell proliferation [IBA]
- response to lipopolysaccharide [IBA]
- response to molecule of bacterial origin [IDA]
Gene Ontology Molecular Function
Affinity Capture-RNA
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and associated RNA species identified by Northern blot, RT-PCR, affinity labeling, sequencing, or microarray analysis.
Publication
Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs.
Lipopolysaccharide (LPS) stimulates production of inflammatory mediators, partly by stabilizing [interleukin-6 (IL-6), cyclooxygenase 2 (COX-2)] and/or stimulating translation [tumour necrosis factor-alpha (TNF-alpha)] of their mRNAs. Such regulation depends on AU-rich elements (AREs) within the 3'-untranslated regions and is partially suppressed by SB 203580 (which inhibits SAPK2a/p38). The LPS-induced production of TNF-alpha and IL-6 is suppressed in MAPKAP-K2-deficient mice (a kinase ... [more]
Throughput
- Low Throughput
Ontology Terms
- raw-264.7 cell (BTO:0003292) [liposaccharide (CHEBI:35740)]
Additional Notes
- LPS stimulated RAW cells, inhibited by SB 203580
Curated By
- BioGRID