TCF21
Gene Ontology Biological Process
- Sertoli cell differentiation [ISS]
- branching involved in ureteric bud morphogenesis [ISS]
- branchiomeric skeletal muscle development [ISS]
- bronchiole development [ISS]
- diaphragm development [ISS]
- embryonic digestive tract morphogenesis [ISS]
- epithelial cell differentiation [ISS]
- gland development [ISS]
- glomerulus development [ISS]
- kidney development [ISS]
- lung alveolus development [ISS]
- lung morphogenesis [ISS]
- lung vasculature development [ISS]
- metanephric glomerular capillary formation [ISS]
- metanephric mesenchymal cell differentiation [ISS]
- morphogenesis of a branching structure [ISS]
- negative regulation of androgen receptor signaling pathway [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- palate development [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- reproductive structure development [ISS]
- respiratory system development [ISS]
- sex determination [ISS]
- spleen development [ISS]
- ureteric bud development [ISS]
- vasculature development [ISS]
Gene Ontology Molecular Function- E-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- androgen receptor binding [ISS]
- bHLH transcription factor binding [IPI]
- protein dimerization activity [ISS]
- E-box binding [ISS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- androgen receptor binding [ISS]
- bHLH transcription factor binding [IPI]
- protein dimerization activity [ISS]
TCF12
Gene Ontology Biological Process
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [IPI]
- bHLH transcription factor binding [IPI]
- enhancer binding [IC]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- SMAD binding [IPI]
- bHLH transcription factor binding [IPI]
- enhancer binding [IC]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Epigenetic deregulation of TCF21 inhibits metastasis suppressor KISS1 in metastatic melanoma.
Metastatic melanoma is a fatal disease due to the lack of successful therapies and biomarkers for early detection and its incidence has been increasing. Genetic studies have defined recurrent chromosomal aberrations, suggesting the location of either tumor suppressor genes or oncogenes. Transcription factor 21 (TCF21) belongs to the class A of the basic helix-loop-helix family with reported functions in early ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TCF21 TCF12 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| TCF12 TCF21 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| TCF21 TCF12 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2717547 |
Curated By
- BioGRID