CTBP2
Gene Ontology Biological Process
- negative regulation of cell proliferation [TAS]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of retinoic acid receptor signaling pathway [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- viral genome replication [TAS]
- white fat cell differentiation [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PROX1
Gene Ontology Biological Process
- aorta smooth muscle tissue morphogenesis [ISS]
- atrial cardiac muscle tissue morphogenesis [ISS]
- brain development [IEP]
- cerebellar granule cell differentiation [ISS]
- dentate gyrus development [ISS]
- dorsal spinal cord development [ISS]
- embryonic retina morphogenesis in camera-type eye [IEP]
- endocardium formation [ISS]
- hepatocyte differentiation [IEP]
- kidney development [IEP]
- lens development in camera-type eye [IEP]
- lens fiber cell morphogenesis [IEP]
- liver development [IEP]
- lung development [IEP]
- lymphangiogenesis [IDA]
- lymphatic endothelial cell differentiation [IDA]
- negative regulation of bile acid biosynthetic process [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- negative regulation of viral genome replication [IDA]
- neural tube development [ISS]
- neuronal stem cell maintenance [ISS]
- olfactory placode formation [ISS]
- optic placode formation involved in camera-type eye formation [ISS]
- otic placode formation [ISS]
- pancreas development [IEP]
- positive regulation of cell cycle [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of forebrain neuron differentiation [ISS]
- positive regulation of heart growth [ISS]
- positive regulation of neural precursor cell proliferation [ISS]
- positive regulation of sarcomere organization [ISS]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of circadian rhythm [IMP]
- regulation of gene expression [IDA]
- regulation of transcription involved in lymphatic endothelial cell fate commitment [IMP]
- retina morphogenesis in camera-type eye [ISS]
- skeletal muscle thin filament assembly [ISS]
- venous blood vessel morphogenesis [ISS]
- ventricular cardiac muscle tissue morphogenesis [ISS]
- ventricular cardiac myofibril assembly [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- DBD domain binding [IPI]
- DNA binding [IMP]
- LBD domain binding [IPI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- core promoter sequence-specific DNA binding [ISS]
- ligand-dependent nuclear receptor binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IC]
- transcription corepressor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- DBD domain binding [IPI]
- DNA binding [IMP]
- LBD domain binding [IPI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- core promoter sequence-specific DNA binding [ISS]
- ligand-dependent nuclear receptor binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IC]
- transcription corepressor activity [IDA]
- transcription regulatory region DNA binding [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Toward an understanding of the protein interaction network of the human liver.
Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CTBP2 PROX1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |
Curated By
- BioGRID