BAIT
ASS1
ASS, CTLN1, RP11-618A20.2
argininosuccinate synthase 1
GO Process (10)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
- arginine biosynthetic process [IBA]
- argininosuccinate metabolic process [IMP]
- aspartate metabolic process [IMP]
- cellular nitrogen compound metabolic process [TAS]
- cellular response to laminar fluid shear stress [IMP]
- citrulline metabolic process [IMP]
- negative regulation of leukocyte cell-cell adhesion [IMP]
- positive regulation of nitric oxide biosynthetic process [IMP]
- small molecule metabolic process [TAS]
- urea cycle [IMP, TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
PTPN1
PTP1B
protein tyrosine phosphatase, non-receptor type 1
GO Process (19)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- JAK-STAT cascade involved in growth hormone signaling pathway [TAS]
- actin cytoskeleton reorganization [IMP]
- blood coagulation [TAS]
- cytokine-mediated signaling pathway [TAS]
- endoplasmic reticulum unfolded protein response [IDA]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of ERK1 and ERK2 cascade [ISS]
- negative regulation of insulin receptor signaling pathway [NAS]
- negative regulation of vascular endothelial growth factor receptor signaling pathway [ISS]
- peptidyl-tyrosine dephosphorylation [IDA, IMP]
- peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity [ISS]
- platelet activation [TAS]
- platelet-derived growth factor receptor-beta signaling pathway [IMP]
- regulation of endocytosis [IDA]
- regulation of hepatocyte growth factor receptor signaling pathway [IMP]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- regulation of signal transduction [IMP]
- regulation of type I interferon-mediated signaling pathway [TAS]
- type I interferon signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Toward an understanding of the protein interaction network of the human liver.
Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]
Mol. Syst. Biol. Oct. 13, 2011; 7(0);536 [Pubmed: 21988832]
Throughput
- High Throughput
Curated By
- BioGRID