BAIT

KPNA3

IPOA4, SRP1, SRP1gamma, SRP4, hSRP1, RP11-432M24.3

karyopherin alpha 3 (importin alpha 4)

GO Process (3)

GO Function (2)

GO Component (3)

Gene Ontology Biological Process

NLS-bearing protein import into nucleus [TAS]

cytokine-mediated signaling pathway [TAS]

protein complex assembly [TAS]

Gene Ontology Molecular Function

nuclear localization sequence binding [TAS]
protein binding [IPI]

Gene Ontology Cellular Component

nuclear pore [TAS]

nucleoplasm [TAS]

CRISPR Database HGNC Alliance of Genome Resources OMIM Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

NFE2L2

NRF2

nuclear factor, erythroid 2-like 2

Alzheimer's Disease Project

Human Papilloma Virus (HPV) Project

GO Process (14)

GO Function (7)

GO Component (6)

Gene Ontology Biological Process

cellular response to fluid shear stress [IDA]

cellular response to hydrogen peroxide [IMP]

cellular response to laminar fluid shear stress [IMP]

cellular response to tumor necrosis factor [IMP]

negative regulation of endothelial cell apoptotic process [IMP]

negative regulation of hydrogen peroxide-induced cell death [IGI]

negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IMP]

positive regulation of gene expression [IGI]

positive regulation of transcription from RNA polymerase II promoter [IC, IDA, IMP]

positive regulation of transcription from RNA polymerase II promoter in response to stress [IMP]

proteasomal ubiquitin-independent protein catabolic process [IDA]

proteasome-mediated ubiquitin-dependent protein catabolic process [IDA]

protein ubiquitination [IDA]

transcription from RNA polymerase II promoter [TAS]

Gene Ontology Molecular Function

DNA binding [IDA]
RNA polymerase II activating transcription factor binding [IPI]
protein binding [IPI]
protein domain specific binding [IPI]
sequence-specific DNA binding transcription factor activity [IDA]
transcription regulatory region DNA binding [TAS]
transcription regulatory region sequence-specific DNA binding [TAS]

Gene Ontology Cellular Component

centrosome [IDA]

cytoplasm [IDA]

nucleoplasm [IDA]

plasma membrane [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Toward an understanding of the protein interaction network of the human liver.

Wang J, Huo K, Ma L, Tang L, Li D, Huang X, Yuan Y, Li C, Wang W, Guan W, Chen H, Jin C, Wei J, Zhang W, Yang Y, Liu Q, Zhou Y, Zhang C, Wu Z, Xu W, Zhang Y, Liu T, Yu D, Zhang Y, Chen L, Zhu D, Zhong X, Kang L, Gan X, Yu X, Ma Q, Yan J, Zhou L, Liu Z, Zhu Y, Zhou T, He F, Yang X

Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]

Mol. Syst. Biol. Oct. 13, 2011; 7(0);536 [Pubmed: 21988832]

Throughput

High Throughput

Curated By

BioGRID