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BAIT

PRRC2A

BAT2, D6S51, D6S51E, G2, DADB-70P7.5

proline-rich coiled-coil 2A

GO Process (0)

GO Function (2)

GO Component (4)

Gene Ontology Molecular Function

poly(A) RNA binding [IDA]
protein binding [IPI]

Gene Ontology Cellular Component

cytoplasm [IDA]

extracellular vesicular exosome [IDA]

intracellular membrane-bounded organelle [IDA]

CRISPR Database HGNC Alliance of Genome Resources OMIM VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

PREY

GRB2

ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084, NCKAP2

growth factor receptor-bound protein 2

GO Process (20)

GO Function (10)

GO Component (10)

Gene Ontology Biological Process

Fc-epsilon receptor signaling pathway [TAS]

Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]

Ras protein signal transduction [TAS]

T cell costimulation [TAS]

axon guidance [TAS]

blood coagulation [TAS]

cell-cell signaling [TAS]

cellular response to ionizing radiation [IMP]

epidermal growth factor receptor signaling pathway [TAS]

fibroblast growth factor receptor signaling pathway [TAS]

innate immune response [TAS]

insulin receptor signaling pathway [IPI, TAS]

leukocyte migration [TAS]

negative regulation of epidermal growth factor receptor signaling pathway [TAS]

neurotrophin TRK receptor signaling pathway [TAS]

phosphatidylinositol-mediated signaling [TAS]

platelet activation [TAS]

positive regulation of reactive oxygen species metabolic process [IMP]

receptor internalization [IMP]

signal transduction in response to DNA damage [IMP]

Gene Ontology Molecular Function

SH3 domain binding [IDA]
SH3/SH2 adaptor activity [TAS]
ephrin receptor binding [IPI]
epidermal growth factor receptor binding [IPI]
identical protein binding [IPI]
insulin receptor substrate binding [IPI]
neurotrophin TRKA receptor binding [IPI]
poly(A) RNA binding [IDA]
protein binding [IPI]
protein kinase binding [IPI]

Gene Ontology Cellular Component

COP9 signalosome [IDA]

Grb2-EGFR complex [IDA]

cytoplasm [IDA]

extracellular vesicular exosome [IDA]

nucleolus [IDA]

nucleoplasm [IDA]

plasma membrane [TAS]

CRISPR Database OMIM HGNC Alliance of Genome Resources VEGA Entrez Gene RefSeq UniprotKB Ensembl HPRD

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Toward an understanding of the protein interaction network of the human liver.

Wang J, Huo K, Ma L, Tang L, Li D, Huang X, Yuan Y, Li C, Wang W, Guan W, Chen H, Jin C, Wei J, Zhang W, Yang Y, Liu Q, Zhou Y, Zhang C, Wu Z, Xu W, Zhang Y, Liu T, Yu D, Zhang Y, Chen L, Zhu D, Zhong X, Kang L, Gan X, Yu X, Ma Q, Yan J, Zhou L, Liu Z, Zhu Y, Zhou T, He F, Yang X

Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]

Mol. Syst. Biol. Oct. 13, 2011; 7(0);536 [Pubmed: 21988832]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
PRRC2A GRB2	Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.	Lehner B (2004)	Low	-	BioGRID	-

Curated By

BioGRID