BAIT

BHLHE40

BHLHB2, DEC1, HLHB2, SHARP-2, STRA13, Stra14

basic helix-loop-helix family, member e40

GO Process (7)

GO Function (14)

GO Component (4)

Gene Ontology Biological Process

circadian regulation of gene expression [IDA]

entrainment of circadian clock by photoperiod [ISS]

negative regulation of sequence-specific DNA binding transcription factor activity [IDA]

negative regulation of transcription from RNA polymerase II promoter [IDA]

negative regulation of transcription, DNA-templated [IDA]

regulation of transcription, DNA-templated [NAS]

transcription from RNA polymerase II promoter [IDA, ISS]

Gene Ontology Molecular Function

E-box binding [IDA]
MRF binding [ISS]
RNA polymerase II activating transcription factor binding [ISS]
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription [IDA]
bHLH transcription factor binding [IPI]
protein binding [IPI]
protein domain specific binding [IPI]
protein heterodimerization activity [IPI]
protein homodimerization activity [IDA]
sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
sequence-specific DNA binding transcription factor activity [NAS]
transcription corepressor activity [IDA]

Gene Ontology Cellular Component

Golgi apparatus [IDA]

nucleolus [IDA]

nucleoplasm [IDA]

nucleus [IDA, NAS]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

HIVEP1

CIRIP, CRYBP1, GAAP, MBP-1, PRDII-BF1, Schnurri-1, ZAS1, ZNF40, ZNF40A, RP3-451B15.2

human immunodeficiency virus type I enhancer binding protein 1

GO Process (0)

GO Function (1)

GO Component (3)

Gene Ontology Molecular Function

protein binding [IPI]

Gene Ontology Cellular Component

mitochondrion [IDA]

nucleoplasm [IDA]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Toward an understanding of the protein interaction network of the human liver.

Wang J, Huo K, Ma L, Tang L, Li D, Huang X, Yuan Y, Li C, Wang W, Guan W, Chen H, Jin C, Wei J, Zhang W, Yang Y, Liu Q, Zhou Y, Zhang C, Wu Z, Xu W, Zhang Y, Liu T, Yu D, Zhang Y, Chen L, Zhu D, Zhong X, Kang L, Gan X, Yu X, Ma Q, Yan J, Zhou L, Liu Z, Zhu Y, Zhou T, He F, Yang X

Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]

Mol. Syst. Biol. Oct. 13, 2011; 7(0);536 [Pubmed: 21988832]

Throughput

High Throughput

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
HIVEP1 BHLHE40	Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.	Luck K (2020)	High	-	BioGRID	2704012

Curated By

BioGRID