BAIT

HIPK2

PRO0593

homeodomain interacting protein kinase 2

Fanconi Anemia Project

GO Process (21)

GO Function (8)

GO Component (4)

Gene Ontology Biological Process

DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator [IDA]

PML body organization [TAS]

SMAD protein signal transduction [IDA]

cellular response to hypoxia [TAS]

erythrocyte differentiation [ISS]

eye development [ISS]

intrinsic apoptotic signaling pathway [NAS]

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [TAS]

modulation by virus of host morphology or physiology [NAS]

negative regulation of BMP signaling pathway [IMP]

peptidyl-serine phosphorylation [ISS]

peptidyl-threonine phosphorylation [ISS]

positive regulation of JNK cascade [IMP]

positive regulation of angiogenesis [IDA]

positive regulation of protein binding [ISS]

positive regulation of sequence-specific DNA binding transcription factor activity [ISS]

positive regulation of transcription from RNA polymerase II promoter [ISS]

positive regulation of transcription, DNA-templated [IMP]

positive regulation of transforming growth factor beta receptor signaling pathway [IMP]

protein phosphorylation [IDA]

regulation of cell cycle [TAS]

Gene Ontology Molecular Function

RNA polymerase II activating transcription factor binding [ISS]
RNA polymerase II transcription coactivator activity [ISS]
SMAD binding [IPI]
protein binding [IPI]
protein kinase activity [IDA]
protein serine/threonine kinase activity [ISS]
transcription corepressor activity [IDA]
virion binding [IPI]

Gene Ontology Cellular Component

cytoplasm [ISS]

nuclear body [IDA, TAS]

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

PREY

MKNK1

MNK1, RP11-49P4.3

MAP kinase interacting serine/threonine kinase 1

GO Process (4)

GO Function (3)

GO Component (1)

Gene Ontology Biological Process

fibroblast growth factor receptor signaling pathway [TAS]

intracellular signal transduction [IDA]

peptidyl-serine phosphorylation [IDA]

protein phosphorylation [IDA]

Gene Ontology Molecular Function

ATP binding [IDA]
protein binding [IPI]
protein serine/threonine kinase activity [IDA]

Gene Ontology Cellular Component

CRISPR Database OMIM HGNC Alliance of Genome Resources Entrez Gene RefSeq UniprotKB Ensembl

Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

Toward an understanding of the protein interaction network of the human liver.

Wang J, Huo K, Ma L, Tang L, Li D, Huang X, Yuan Y, Li C, Wang W, Guan W, Chen H, Jin C, Wei J, Zhang W, Yang Y, Liu Q, Zhou Y, Zhang C, Wu Z, Xu W, Zhang Y, Liu T, Yu D, Zhang Y, Chen L, Zhu D, Zhong X, Kang L, Gan X, Yu X, Ma Q, Yan J, Zhou L, Liu Z, Zhu Y, Zhou T, He F, Yang X

Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]

Mol. Syst. Biol. Oct. 13, 2011; 7(0);536 [Pubmed: 21988832]

Throughput

High Throughput

Curated By

BioGRID