BAIT
MRPS6
C21orf101, MRP-S6, RPMS6, S6mt
mitochondrial ribosomal protein S6
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SREBF2
SREBP-2, SREBP2, bHLHd2, CTA-250D10.14-005
sterol regulatory element binding transcription factor 2
GO Process (10)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- cellular lipid metabolic process [TAS]
- cellular response to laminar fluid shear stress [NAS]
- lipid metabolic process [TAS]
- negative regulation of cholesterol efflux [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of cholesterol storage [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter [IDA]
- response to low-density lipoprotein particle [IEP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- C-8 sterol isomerase activity [IDA]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- C-8 sterol isomerase activity [IDA]
- E-box binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription [IDA]
- protein C-terminus binding [IPI]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Toward an understanding of the protein interaction network of the human liver.
Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]
Mol. Syst. Biol. Oct. 13, 2011; 7(0);536 [Pubmed: 21988832]
Throughput
- High Throughput
Curated By
- BioGRID