BAIT
MAP2K5
HsT17454, MAPKK5, MEK5, PRKMK5
mitogen-activated protein kinase kinase 5
GO Process (16)
GO Function (2)
GO Component (0)
Gene Ontology Biological Process
- activation of MAPK activity [ISS]
- cellular response to growth factor stimulus [ISS]
- cellular response to laminar fluid shear stress [TAS]
- negative regulation of NF-kappaB transcription factor activity [ISS]
- negative regulation of cell migration involved in sprouting angiogenesis [ISS]
- negative regulation of chemokine (C-X-C motif) ligand 2 production [ISS]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISS]
- negative regulation of heterotypic cell-cell adhesion [ISS]
- negative regulation of interleukin-8 biosynthetic process [ISS]
- negative regulation of response to cytokine stimulus [ISS]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- neurotrophin TRK receptor signaling pathway [TAS]
- positive regulation of protein metabolic process [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
XRCC6
CTC75, CTCBF, G22P1, KU70, ML8, TLAA, CTA-216E10.7
X-ray repair complementing defective repair in Chinese hamster cells 6
GO Process (13)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- DNA duplex unwinding [TAS]
- DNA ligation [TAS]
- DNA repair [TAS]
- double-strand break repair [TAS]
- double-strand break repair via nonhomologous end joining [IMP, TAS]
- establishment of integrated proviral latency [TAS]
- innate immune response [TAS]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- positive regulation of transcription, DNA-templated [IDA, IMP]
- positive regulation of type I interferon production [TAS]
- telomere maintenance [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Toward an understanding of the protein interaction network of the human liver.
Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]
Mol. Syst. Biol. Oct. 13, 2011; 7(0);536 [Pubmed: 21988832]
Throughput
- High Throughput
Curated By
- BioGRID