BAIT
PROX1
prospero homeobox 1
GO Process (47)
GO Function (10)
GO Component (2)
Gene Ontology Biological Process
- aorta smooth muscle tissue morphogenesis [ISS]
- atrial cardiac muscle tissue morphogenesis [ISS]
- brain development [IEP]
- cerebellar granule cell differentiation [ISS]
- dentate gyrus development [ISS]
- dorsal spinal cord development [ISS]
- embryonic retina morphogenesis in camera-type eye [IEP]
- endocardium formation [ISS]
- hepatocyte differentiation [IEP]
- kidney development [IEP]
- lens development in camera-type eye [IEP]
- lens fiber cell morphogenesis [IEP]
- liver development [IEP]
- lung development [IEP]
- lymphangiogenesis [IDA]
- lymphatic endothelial cell differentiation [IDA]
- negative regulation of bile acid biosynthetic process [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- negative regulation of viral genome replication [IDA]
- neural tube development [ISS]
- neuronal stem cell maintenance [ISS]
- olfactory placode formation [ISS]
- optic placode formation involved in camera-type eye formation [ISS]
- otic placode formation [ISS]
- pancreas development [IEP]
- positive regulation of cell cycle [ISS]
- positive regulation of cell proliferation [IDA]
- positive regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- positive regulation of endothelial cell migration [IDA]
- positive regulation of endothelial cell proliferation [IDA]
- positive regulation of forebrain neuron differentiation [ISS]
- positive regulation of heart growth [ISS]
- positive regulation of neural precursor cell proliferation [ISS]
- positive regulation of sarcomere organization [ISS]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of circadian rhythm [IMP]
- regulation of gene expression [IDA]
- regulation of transcription involved in lymphatic endothelial cell fate commitment [IMP]
- retina morphogenesis in camera-type eye [ISS]
- skeletal muscle thin filament assembly [ISS]
- venous blood vessel morphogenesis [ISS]
- ventricular cardiac muscle tissue morphogenesis [ISS]
- ventricular cardiac myofibril assembly [ISS]
- ventricular septum morphogenesis [ISS]
Gene Ontology Molecular Function- DBD domain binding [IPI]
- DNA binding [IMP]
- LBD domain binding [IPI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- core promoter sequence-specific DNA binding [ISS]
- ligand-dependent nuclear receptor binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IC]
- transcription corepressor activity [IDA]
- transcription regulatory region DNA binding [IDA]
- DBD domain binding [IPI]
- DNA binding [IMP]
- LBD domain binding [IPI]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [ISS]
- core promoter sequence-specific DNA binding [ISS]
- ligand-dependent nuclear receptor binding [IPI]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [IC]
- transcription corepressor activity [IDA]
- transcription regulatory region DNA binding [IDA]
Homo sapiens
PREY
SMAD3
HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3
SMAD family member 3
GO Process (35)
GO Function (24)
GO Component (10)
Gene Ontology Biological Process
- SMAD protein complex assembly [IDA]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- activin receptor signaling pathway [IMP]
- cell cycle arrest [IMP]
- cell-cell junction organization [IMP]
- evasion or tolerance of host defenses by virus [IDA]
- extrinsic apoptotic signaling pathway [IMP]
- gene expression [TAS]
- immune response [IMP]
- intracellular signal transduction [IDA]
- negative regulation of cell growth [IDA]
- negative regulation of mitotic cell cycle [IMP]
- negative regulation of protein catabolic process [IMP]
- negative regulation of protein phosphorylation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [TAS]
- nodal signaling pathway [IMP]
- positive regulation of canonical Wnt signaling pathway [IMP]
- positive regulation of catenin import into nucleus [IMP]
- positive regulation of epithelial to mesenchymal transition [IDA, IMP]
- positive regulation of gene expression [IDA]
- positive regulation of transcription factor import into nucleus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP, TAS]
- positive regulation of transcription, DNA-templated [IDA]
- primary miRNA processing [TAS]
- protein stabilization [IMP]
- regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transforming growth factor beta receptor signaling pathway [IMP]
- regulation of transforming growth factor beta2 production [IMP]
- response to hypoxia [IMP]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [IDA, TAS]
- transport [IDA]
- wound healing [TAS]
Gene Ontology Molecular Function- R-SMAD binding [IPI]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- bHLH transcription factor binding [IPI]
- beta-catenin binding [IPI]
- co-SMAD binding [IPI]
- core promoter proximal region sequence-specific DNA binding [IDA]
- enhancer binding [IC]
- identical protein binding [IPI]
- phosphatase binding [IPI]
- protein binding [IPI]
- protein binding transcription factor activity [IDA]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- transforming growth factor beta receptor binding [IPI]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [IDA]
- ubiquitin binding [IDA]
- ubiquitin protein ligase binding [IPI]
- zinc ion binding [IDA]
- R-SMAD binding [IPI]
- RNA polymerase II activating transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [IDA]
- bHLH transcription factor binding [IPI]
- beta-catenin binding [IPI]
- co-SMAD binding [IPI]
- core promoter proximal region sequence-specific DNA binding [IDA]
- enhancer binding [IC]
- identical protein binding [IPI]
- phosphatase binding [IPI]
- protein binding [IPI]
- protein binding transcription factor activity [IDA]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IPI]
- transcription regulatory region DNA binding [IDA]
- transforming growth factor beta receptor binding [IPI]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [IDA]
- ubiquitin binding [IDA]
- ubiquitin protein ligase binding [IPI]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Toward an understanding of the protein interaction network of the human liver.
Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]
Mol. Syst. Biol. Oct. 13, 2011; 7(0);536 [Pubmed: 21988832]
Throughput
- High Throughput
Curated By
- BioGRID