BAIT
MDM2
ACTFS, HDMX, hdm2
MDM2 proto-oncogene, E3 ubiquitin protein ligase
GO Process (25)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest [IMP, TAS]
- Fc-epsilon receptor signaling pathway [TAS]
- cellular response to hypoxia [IEP]
- epidermal growth factor receptor signaling pathway [TAS]
- establishment of protein localization [IDA]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- negative regulation of DNA damage response, signal transduction by p53 class mediator [IDA]
- negative regulation of cell cycle arrest [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-lysine modification [IMP]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of cell proliferation [TAS]
- positive regulation of mitotic cell cycle [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- protein complex assembly [IDA]
- protein destabilization [IDA]
- protein localization to nucleus [IDA]
- protein ubiquitination [IDA]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA]
- regulation of protein catabolic process [IDA]
- response to antibiotic [IEP]
- synaptic transmission [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
WT1
AWT1, EWS-WT1, GUD, NPHS4, WAGR, WIT-2, WT33
Wilms tumor 1
GO Process (47)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- RNA splicing [ISS]
- adrenal cortex formation [ISS]
- adrenal gland development [IGI]
- branching involved in ureteric bud morphogenesis [IGI]
- camera-type eye development [ISS]
- cardiac muscle cell fate commitment [ISS]
- cellular response to cAMP [IEP]
- cellular response to gonadotropin stimulus [IDA]
- diaphragm development [ISS]
- epithelial cell differentiation [ISS]
- germ cell development [ISS]
- glomerular basement membrane development [IMP]
- glomerular visceral epithelial cell differentiation [IBA, ISS]
- glomerulus development [IGI]
- gonad development [ISS]
- heart development [IGI]
- kidney development [IGI]
- male genitalia development [ISS]
- male gonad development [IEP]
- mesenchymal to epithelial transition [ISS]
- metanephric S-shaped body morphogenesis [IGI]
- metanephric epithelium development [IEP]
- metanephric mesenchyme development [ISS]
- negative regulation of apoptotic process [IGI]
- negative regulation of cell growth [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of female gonad development [ISS]
- negative regulation of metanephric glomerular mesangial cell proliferation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of translation [IDA]
- positive regulation of apoptotic process [IDA]
- positive regulation of heart growth [ISS]
- positive regulation of male gonad development [ISS]
- positive regulation of metanephric ureteric bud development [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA, IGI]
- posterior mesonephric tubule development [ISS]
- regulation of organ formation [ISS]
- regulation of transcription from RNA polymerase II promoter [ISS]
- regulation of transcription, DNA-templated [ISS, NAS]
- sex determination [IDA]
- thorax and anterior abdomen determination [ISS]
- tissue development [ISS]
- ureteric bud development [ISS]
- vasculogenesis [ISS]
- visceral serous pericardium development [IGI]
Gene Ontology Molecular Function- C2H2 zinc finger domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISS, NAS]
- transcription regulatory region DNA binding [IDA]
- zinc ion binding [IDA]
- C2H2 zinc finger domain binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [ISS]
- protein binding [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [ISS, NAS]
- transcription regulatory region DNA binding [IDA]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
- cytoplasm [IBA, ISS]
- nuclear speck [IDA]
- nucleoplasm [IDA]
- nucleus [IDA]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Toward an understanding of the protein interaction network of the human liver.
Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]
Mol. Syst. Biol. Oct. 13, 2011; 7(0);536 [Pubmed: 21988832]
Throughput
- High Throughput
Curated By
- BioGRID