BAIT
NUMBL
CAG3A, CTG3a, NBL, NUMB-R, NUMBLIKE, NUMBR, TNRC23
numb homolog (Drosophila)-like
GO Process (6)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
PREY
RIPK1
RIP, RIP1
receptor (TNFRSF)-interacting serine-threonine kinase 1
GO Process (42)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell apoptotic process [ISS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of JUN kinase activity [TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- amyloid fibril formation [IMP]
- apoptotic process [IMP, TAS]
- apoptotic signaling pathway [TAS]
- cellular protein catabolic process [IDA]
- cellular response to tumor necrosis factor [IDA]
- extrinsic apoptotic signaling pathway [IDA, IMP]
- innate immune response [TAS]
- necroptotic process [IMP]
- necroptotic signaling pathway [IMP, ISS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- peptidyl-serine autophosphorylation [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, IEP]
- positive regulation of JNK cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of apoptotic process [IDA, IMP]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of macrophage differentiation [IMP]
- positive regulation of necroptotic process [IMP]
- positive regulation of programmed cell death [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of reactive oxygen species metabolic process [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor production [IDA]
- positive regulation of type I interferon production [TAS]
- protein autophosphorylation [IDA]
- protein heterooligomerization [IMP]
- protein homooligomerization [IDA]
- regulation of ATP:ADP antiporter activity [IMP]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- response to tumor necrosis factor [IMP]
- ripoptosome assembly [IMP]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- tumor necrosis factor-mediated signaling pathway [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Toward an understanding of the protein interaction network of the human liver.
Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]
Mol. Syst. Biol. Oct. 13, 2011; 7(0);536 [Pubmed: 21988832]
Throughput
- High Throughput
Curated By
- BioGRID