BAIT
IRAK3
ASRT5, IRAKM
interleukin-1 receptor-associated kinase 3
GO Process (24)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- MyD88-dependent toll-like receptor signaling pathway [TAS]
- cytokine-mediated signaling pathway [ISS]
- interleukin-1-mediated signaling pathway [IMP]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of NF-kappaB transcription factor activity [IMP]
- negative regulation of cytokine-mediated signaling pathway [IC]
- negative regulation of innate immune response [ISS]
- negative regulation of interleukin-12 production [IMP, ISS]
- negative regulation of interleukin-6 production [IMP, ISS]
- negative regulation of macrophage cytokine production [ISS]
- negative regulation of protein catabolic process [IMP]
- negative regulation of protein complex disassembly [IMP]
- negative regulation of toll-like receptor signaling pathway [ISS]
- negative regulation of tumor necrosis factor production [IMP]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of macrophage tolerance induction [ISS]
- protein phosphorylation [IDA]
- regulation of protein complex disassembly [ISS]
- response to exogenous dsRNA [ISS]
- response to interleukin-1 [IMP]
- response to lipopolysaccharide [ISS]
- response to peptidoglycan [ISS]
- response to virus [IC]
- toll-like receptor signaling pathway [IBA]
Gene Ontology Molecular Function
Homo sapiens
PREY
LDB1
CLIM2, NLI
LIM domain binding 1
GO Process (11)
GO Function (5)
GO Component (4)
Gene Ontology Biological Process
- histone H3-K4 acetylation [ISS]
- multicellular organismal development [NAS]
- negative regulation of erythrocyte differentiation [ISS]
- negative regulation of transcription, DNA-templated [IDA]
- neuron differentiation [ISS]
- positive regulation of hemoglobin biosynthetic process [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IMP, ISS]
- regulation of DNA-templated transcription, elongation [ISS]
- regulation of transcription, DNA-templated [NAS]
- transcription, DNA-templated [NAS]
- transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Toward an understanding of the protein interaction network of the human liver.
Proteome-scale protein interaction maps are available for many organisms, ranging from bacteria, yeast, worms and flies to humans. These maps provide substantial new insights into systems biology, disease research and drug discovery. However, only a small fraction of the total number of human protein-protein interactions has been identified. In this study, we map the interactions of an unbiased selection of ... [more]
Mol. Syst. Biol. Oct. 13, 2011; 7(0);536 [Pubmed: 21988832]
Throughput
- High Throughput
Curated By
- BioGRID